There's more to life than bacteria

Young, Gillian

doi:10.1038/nrmicro1753

Cited by 2 publications

(3 citation statements)

References 2 publications

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“…The study of riboregulation in H. pylori will also help to understand post-transcriptional regulation in other Epsilonproteobacteria, such as the emerging pathogen Campylobacter jejuni , which is considered as the leading cause of bacterial gastroenteritis (Young et al, 2007). Recently, first sRNA candidates have also been identified in C. jejuni NCTC11168 based on conventional RNA-seq combined with predictions of conserved RNA structures (Chaudhuri et al, 2011).…”

Section: Perspectivementioning

confidence: 99%

Transcriptome Complexity and Riboregulation in the Human Pathogen Helicobacter pylori

Pernitzsch¹,

Sharma²

2012

Front. Cell. Inf. Microbio.

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The Gram-negative Epsilonproteobacterium Helicobacter pylori is considered as one of the major human pathogens and many studies have focused on its virulence mechanisms as well as genomic diversity. In contrast, only very little is known about post-transcriptional regulation and small regulatory RNAs (sRNAs) in this spiral-shaped microaerophilic bacterium. Considering the absence of the common RNA chaperone Hfq, which is a key-player in post-transcriptional regulation in enterobacteria, H. pylori was even regarded as an organism without riboregulation. However, analysis of the H. pylori primary transcriptome using RNA-seq revealed a very complex transcriptional output from its small genome. Furthermore, the identification of a wealth of sRNAs as well as massive antisense transcription indicates that H. pylori uses riboregulation for its gene expression control. The ongoing functional characterization of sRNAs along with the identification of associated RNA binding proteins will help to understand their potential roles in Helicobacter virulence and stress response. Moreover, research on riboregulation in H. pylori will provide new insights into its virulence mechanisms and will also help to shed light on post-transcriptional regulation in other Epsilonproteobacteria, including widespread and emerging pathogens such as Campylobacter.

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Section: Perspectivementioning

confidence: 99%

Transcriptome Complexity and Riboregulation in the Human Pathogen Helicobacter pylori

Pernitzsch¹,

Sharma²

2012

Front. Cell. Inf. Microbio.

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“…Infections with C. jejuni are the major cause of human bacterial gastroenteritis, and may be responsible for as many as 400–500 million cases worldwide each year (Friedman et al, 2000). Disease outcomes vary from mild, non-inflammatory, self-limiting diarrhea to severe, inflammatory, bloody diarrhea lasting for several weeks, but C. jejuni is also associated with the development of the reactive arthritis and peripheral neuropathies, the Miller–Fisher and Guillain–Barrè syndromes in a minority of individuals (Young et al, 2007). The publication of numerous complete genome sequences of different C. jejuni strains has revealed an organism that displays a large degree of strain to strain variation.…”

Section: Introductionmentioning

confidence: 99%

“…However, significant progress has been made in recent years which has contributed to our understanding of the role of several key factors including the cytolethal distending toxin (Lara-Tejero and Galán, 2000; Ge et al, 2008) as well as glycosylation and molecular mimicry processes (Guerry and Szymanski, 2008; Nothaft and Szymanski, 2010). One of the key differences between infection of humans and chickens by C. jejuni is the apparently increased number of bacteria invading epithelial cells in the human host (Young et al, 2007). This suggests that both bacterial adherence to and entrance into epithelial cells may be critical steps that are essential for disease development.…”

Section: Introductionmentioning

confidence: 99%

Host Epithelial Cell Invasion by Campylobacter jejuni: Trigger or Zipper Mechanism?

Cróinı́n¹,

Backert²

2012

Front. Cell. Inf. Microbio.

129

111

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Campylobacter jejuni, a spiral-shaped Gram-negative pathogen, is a highly frequent cause of gastrointestinal foodborne illness in humans worldwide. Clinical outcome of C. jejuni infections ranges from mild to severe diarrheal disease, and some other complications including reactive arthritis and Guillain–Barré syndrome. This review article highlights various C. jejuni pathogenicity factors, host cell determinants, and proposed signaling mechanisms involved in human host cell invasion and their potential role in the development of C. jejuni-mediated disease. A model is presented which outlines the various important interactions of C. jejuni with the intestinal epithelium, and we discuss the pro’s and con’s for the “zipper” over the “trigger” mechanism of invasion. Future work should clarify the contradictory role of some previously identified factors, and should identify and characterize novel virulence determinants, which are crucial to provide fresh insights into the diversity of strategies employed by this pathogen to cause disease.

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There's more to life than bacteria

Cited by 2 publications

References 2 publications

Transcriptome Complexity and Riboregulation in the Human Pathogen Helicobacter pylori

Transcriptome Complexity and Riboregulation in the Human Pathogen Helicobacter pylori

Host Epithelial Cell Invasion by Campylobacter jejuni: Trigger or Zipper Mechanism?

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