There’s no such fool like an immunosenescent fool

Seidel, Markus G.

doi:10.1182/blood-2014-12-614149

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Tpp2 Deficiency1

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Cited by 2 publications

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“…It has been theorized that the defective TPP2 is unable to control senescence leading to this clinical and immunological features, akin to those that happen gradually in the normal aging of the immune system, but in a more "acute" process [59].…”

Section: Tpp2 Deficiencymentioning

confidence: 99%

From Primary Immunodeficiency to Autoimmunity: How Extreme Situations Highlight the Main Genetic Factors Involved in Autoimmune Disease

Juan¹

2016

MOJI

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Section: Tpp2 Deficiencymentioning

confidence: 99%

From Primary Immunodeficiency to Autoimmunity: How Extreme Situations Highlight the Main Genetic Factors Involved in Autoimmune Disease

Juan¹

2016

MOJI

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Natural History, Pathogenesis, and Treatment of Evans Syndrome in Children

Mantadakis

Farmaki

2017

Journal of Pediatric Hematology/Oncology

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Primary Evans syndrome (ES) is defined by the concurrent or sequential occurrence of immune thrombocytopenia and autoimmune hemolytic anemia in the absence of an underlying etiology. The syndrome is characterized by a chronic, relapsing, and potentially fatal course requiring long-term immunosuppressive therapy. Treatment of ES is hardly evidence-based. Corticosteroids are the mainstay of therapy. Rituximab has emerged as the most widely used second-line treatment, as it can safely achieve high response rates and postpone splenectomy. An increasing number of new genetic defects involving critical pathways of immune regulation identify specific disorders, which explain cases of ES previously reported as "idiopathic".

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There’s no such fool like an immunosenescent fool

Cited by 2 publications

References 10 publications

From Primary Immunodeficiency to Autoimmunity: How Extreme Situations Highlight the Main Genetic Factors Involved in Autoimmune Disease

From Primary Immunodeficiency to Autoimmunity: How Extreme Situations Highlight the Main Genetic Factors Involved in Autoimmune Disease

Natural History, Pathogenesis, and Treatment of Evans Syndrome in Children

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