The purpose of this study was to examine the variables associated with adult undergraduates’ food and housing insecurity during the COVID-19 pandemic. Data were derived from the 2020 #RealCollege Survey, which was completed by 25,838 adult undergraduates (≥25 years old) at 72 4-year and 127 2-year institutions in 42 U.S. states. The results suggest that 43.2% of adult undergraduates experienced food insecurity, and 60.6% experienced housing insecurity. Adult undergraduates who had multiple disabilities, grew up in lower-income families, had previously lived in foster care, attended 2-year colleges, and did not live with a spouse/partner had significantly higher probabilities of experiencing food or housing insecurity. Furthermore, first-generation students, international students, or caregivers, parents, or guardians to children had significantly higher probabilities of experiencing food and housing insecurity. Finally, adult undergraduates who experienced COVID-19 pandemic-related academic and financial and health difficulties also had higher probabilities of experiencing food and housing insecurity.