Thermal analysis of a calcium fructoborate sample

Rotaru, P.; Scorei, Ion Romulus; Harabor, A.; Dumitru, Marius

doi:10.1016/j.tca.2010.04.006

Cited by 40 publications

(36 citation statements)

References 32 publications

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“…FruiteX-B® calcium fructoborate is a natureidentical borate complex in the food-form naturally found in fruits, vegetables, nuts, and legumes [8]. The chemistry of FrxB is revealed here in order to show the distinct characteristics of this plant-based mineral complex.…”

Section: Chemistry Studymentioning

confidence: 94%

Short-term Intake of Calcium Fructoborate Improves WOMAC and McGill Scores and Beneficially Modulates Biomarkers Associated with Knee Osteoarthritis: A Pilot Clinical Double-blinded Placebo-controlled Study

Reyes-Izquierdo¹,

Nemzer²,

Gonzalez³

et al. 2012

Am. J. Biomed. Sci.

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Knee osteoarthritis (OA) is a common degenerative joint disease which contributes significantly to the burden of physical disability. Conventional management of OA mainly focuses on relief of symptoms using analgesics and non-steroidal anti-inflammatory drugs (NSAIDs). Some dietary supplements have shown some potency to reduce symptoms associated with OA conditions. Calcium Fructoborate (commercially marketed under the trade name FruiteX-B®), is a naturally occurring borate complex as first described by Patrick Brown [1]. For this study, FruiteX-B® was characterized by NMR and data from solid and liquidstate 11 B NMR have been obtained and compared against boric acid and fructose for quality purposes. In this study, FruiteX-B® was tested for fourteen days at a serving of 108 mg twice a day on subjects diagnosed with minor osteoarthritis conditions of the knees by CT scan. FruiteX-B® was well tolerated by all study subjects with no reports of adverse effect and resulted in several positive outcomes. On Day 14, WOMAC and McGill indexes were reduced by an average 29% and 14% respectively over Day 1 pre-ingestion values. Blood level of C-Reactive Protein (CRP) in 7 out of 10 subjects was found reduced up to 37% compared to Day 1 baseline levels. Interestingly, the study also showed that blood level of endogenous 1, 25(OH) vitamin D was increased more than 19% compared to baseline. However, differences in 25(OH) vitamin D were not observed. These results indicate that FruiteX-B® at a serving as low as 108mg twice a day provides significant benefits to people experiencing conditions associated with knee osteoarthritis. On the basis of these results, a larger clinical efficacy study is highly justified.

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Section: Chemistry Studymentioning

confidence: 94%

Short-term Intake of Calcium Fructoborate Improves WOMAC and McGill Scores and Beneficially Modulates Biomarkers Associated with Knee Osteoarthritis: A Pilot Clinical Double-blinded Placebo-controlled Study

Reyes-Izquierdo¹,

Nemzer²,

Gonzalez³

et al. 2012

Am. J. Biomed. Sci.

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“…[7][8][9] CFB is a patented plant mineral compound, which is displayed and sold as bulk as a nutritional supplement under the name of FruiteX-B ® (FrxB), 10 a nature-identical analogue of a plant mineral complex with potential health benefits for conditions associated with inflammation of the bone, joint and cardiovascular system. [6][7][8][9][10][11][12] In the past, quantification of boronic/boric/borate esters has been performed using liquid and solid 11 B-NMR, 11,13,14 TLC, [15][16][17] HPLC coupled with UV or fluorometric detection, 18 thermal analysis, X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), Raman and inductively coupled plasma (ICP) spectroscopy 19 either alone or in combination with other compounds.…”

Section: Introductionmentioning

confidence: 99%

“…The molecular formula of calcium fructoborate diester has been identified to be Ca[(C6H10O6)2B]2·4H2O. 19 In this paper, we describe a new, simple, fast, precise and specific HPTLC-densitometric analysis for the simultaneous quantitation of BA and CFB in bulk and tablets/capsules of dietary supplements. Recently, we have used this method for the estimation and validation of total boron and CFB in some foodstuffs.…”

Section: Introductionmentioning

confidence: 99%

Simultaneous Quantitation of Boric Acid and Calcium Fructoborate in Dietary Supplements by HPTLC-Densitometry

et al. 2017

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The paper describes a new, simple, selective and precise high-performance thin-layer chromatographic (HPTLC) method for the simultaneous identification and quantitative determination of boric acid (BA) and calcium fructoborate (CFB) in bulk and tablet/capsule dosage forms of dietary supplements. HPTLC silica gel G 60 F254 precoated glass plates were used as the stationary phase. The mobile phase consisted of 2-propanol-water 8:2 (v/v). The two boron-based compounds were adequately separated with the Rf values of 0.83 ± 0.01 (BA) and 0.59 ± 0.01 (CFB).

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“…Thermal analysis is frequently used to determine the thermal stability and phase transformations of organic and inorganic materials [24][25][26][27][28][29][30][31][32][33][34][35][36][37][38].…”

Section: Resultsmentioning

confidence: 99%

Thermal properties, texture, second-order stress, and magnetic susceptibility of the Bi1.8Pb0.3Sr2Ca2Cu3.3Ox

Harabor

Rotaru

Harabor

2014

J Therm Anal Calorim

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Mono-phase high critical temperature (Bi,Pb)-2223 superconductor from the off-stoichiometric Bi 1.8 Pb 0.3 Sr 2 Ca 2 Cu 3.3 O x belonging to the tetragonal system, has been obtained. We studied the crystalline structure, the stress of second order, and the texture of the surface pellet, in the framework of XRD diffractometry. Results of the thermal measurements made in the nitrogen, with a heating rate of 10 K min -1 , from room temperature (RT) to 1273.15 K, show a slow mass decrease of 1.25 % from RT to 1003.15 K probably due to the elimination of water, oxygen, and of the other gases accumulated on the crystallite surface through chemical adsorption. Two endothermic processes were evidenced on DSC, and DTG curves: the first in the range of 1135.15-1193.15 K (melting and slow decomposition), and another after 1217.45 K (decomposition). The contribution of crystal lattice to the estimated specific heat capacity was in conformity with the Einstein model, giving for the Einstein temperature a value of 1297.5 K. In conformity with the Müller critical state model, we found linear dependences for intragrain critical transition temperature, T g , and intergrain coupling temperature, T p , versus the amplitude of the external AC magnetic fields. There was evidenced that intergrain critical currents are five orders smaller than the intragrain critical currents.

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Thermal analysis of a calcium fructoborate sample

Cited by 40 publications

References 32 publications

Short-term Intake of Calcium Fructoborate Improves WOMAC and McGill Scores and Beneficially Modulates Biomarkers Associated with Knee Osteoarthritis: A Pilot Clinical Double-blinded Placebo-controlled Study

Short-term Intake of Calcium Fructoborate Improves WOMAC and McGill Scores and Beneficially Modulates Biomarkers Associated with Knee Osteoarthritis: A Pilot Clinical Double-blinded Placebo-controlled Study

Simultaneous Quantitation of Boric Acid and Calcium Fructoborate in Dietary Supplements by HPTLC-Densitometry

Thermal properties, texture, second-order stress, and magnetic susceptibility of the Bi1.8Pb0.3Sr2Ca2Cu3.3Ox

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