Thermal and Photo Stability of Glutathione-Capped Cadmium Telluride Quantum Dots

Wansapura, Poorna T.; Díaz-Vásquez, Waldo A.; Vásquez, Claudio C.; Pérez-Donoso, José M.; Chasteen, Thomas G.

doi:10.5301/jabfm.5000221

Cited by 4 publications

(5 citation statements)

References 8 publications

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“…This is confirmed by observing the color of the films under UV light (Figure ). Chitin–CdTeQD hybrid film exhibits intense florescence yellow color which is a unique characteristic of CdTeQDs . Chitin films do not fluoresce under UV light.…”

Section: Resultsmentioning

confidence: 99%

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Preparation of chitin‐CdTe quantum dots films and antibacterial effect on Staphylococcus aureus and Pseudomonas aeruginosa

Wansapura

Dassanayake

Hamood³

et al. 2017

J of Applied Polymer Sci

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Novel chitin–cadmium‐tellurium quantum dot (Chitin‐CdTeQD) hybrid films combining chitin and CdTe quantum dots (CdTeQDs) were prepared via a facile aqueous synthesis route at room temperature. Films were characterized by high‐resolution field emission scanning electron microscopy (HR‐FESEM) and energy dispersive X‐ray (EDX) spectroscopy, Fourier transform infrared (FTIR) spectroscopy, thermogravimetric analysis (TGA), and X‐ray diffraction analysis (XRD). Antibacterial activity was studied on both Gram‐positive (Staphylococcus aureus) and Gram‐negative (Pseudomonas aeruginosa) bacteria. Antibacterial properties were investigated with agar diffusion testing assay and with confocal laser scanning microscopic image analysis. Chitin–CdTeQD films exhibited an excellent antibacterial activity against both Gram‐positive and Gram‐negative bacteria. Chitin–CdTeQD films might be a desirable antibacterial material for wide range of biomedical applications including wound dressing, burn treatment, drug delivery systems, packaging, ophthalmology, and implants. © 2017 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2017, 134, 44904.

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Section: Resultsmentioning

confidence: 99%

“…QDs were synthesized using a facile aqueous route reported in the literature . A typical synthesis method involved the reduction of tellurium oxyanions with glutathione (GSH) in the presence of cadmium cations in a citrate‐borax buffer solution.…”

Section: Methodsmentioning

confidence: 99%

Preparation of chitin‐CdTe quantum dots films and antibacterial effect on Staphylococcus aureus and Pseudomonas aeruginosa

Wansapura

Dassanayake

Hamood³

et al. 2017

J of Applied Polymer Sci

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“…The nanocrystals exhibited diffraction peaks at 25.5°, 28.5° and 45.7°, which are slightly shifted with respect to the position of the diffraction peaks belonging to the most stable crystalline phase of CdTe [ 44 ]. Various reports indicate that this shift is due to induced stresses by the GSH stabilization, possibly due to the incorporation of sulfide ions into the CdTe nanocrystals [ 24 , 54 , 55 ].…”

Section: Resultsmentioning

confidence: 99%

Physico-Chemical Properties of CdTe/Glutathione Quantum Dots Obtained by Microwave Irradiation for Use in Monoclonal Antibody and Biomarker Testing

Ruiz-Robles,

Solís-Pomar,

Travieso Aguilar

et al. 2024

Nanomaterials

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In this report, we present the results on the physicochemical characterization of cadmium telluride quantum dots (QDs) stabilized with glutathione and prepared by optimizing the synthesis conditions. An excellent control of emissions and the composition of the nanocrystal surface for its potential application in monoclonal antibody and biomarker testing was achieved. Two samples (QDYellow, QDOrange, corresponding to their emission colors) were analyzed by dynamic light scattering (DLS), and their hydrodynamic sizes were 6.7 nm and 19.4 nm, respectively. Optical characterization by UV-vis absorbance spectroscopy showed excitonic peaks at 517 nm and 554 nm. Photoluminescence spectroscopy indicated that the samples have a maximum intensity emission at 570 and 606 nm, respectively, within the visible range from yellow to orange. Infrared spectroscopy showed vibrational modes corresponding to the functional groups OH-C-H, C-N, C=C, C-O, C-OH, and COOH, which allows for the formation of functionalized QDs for the manufacture of biomarkers. In addition, the hydrodynamic radius, zeta potential, and approximate molecular weight were determined by dynamic light scattering (DLS), electrophoretic light scattering (ELS), and static light scattering (SLS) techniques. Size dispersion and the structure of nanoparticles was obtained by Transmission Electron Microscopy (TEM) and by X-ray diffraction. In the same way, we calculated the concentration of Cd2+ ions expressed in mg/L by using the Inductively Coupled Plasma Atomic Emission Spectrometry (ICP-OES). In addition to the characterization of the nanoparticles, the labeling of murine myeloid cells was carried out with both samples of quantum dots, where it was demonstrated that quantum dots can diffuse into these cells and connect mostly with the cell nucleus.

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“…In addition, the higher pH value resulted in the lower release rate. This can be explained that glutathione was most appropriate to preserve in an acidic pH environment, oxidation during incubation may cause glutathione instability when in a nonacidic environment, thus affecting the results of controlled release. − …”

Section: Resultsmentioning

confidence: 99%

Anti-Tumor Metastasis via Platelet Inhibitor Combined with Photothermal Therapy under Activatable Fluorescence/Magnetic Resonance Bimodal Imaging Guidance

Zhang

Sun

et al. 2021

ACS Appl. Mater. Interfaces

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Photothermal therapy (PTT) is a promising tumor therapy strategy; however, heterogeneous heat distribution over the tumor often exists, resulting in insufficient photothermal ablation and potential risk of cancer metastasis, which has been demonstrated to be associate with platelets. Herein, a near-infrared (NIR) photothermal agent of IR780 was conjugated with MRI agent of Gd-DOTA via a disulfide linkage (ICD-Gd), which was coassembly with lipid connecting tumor-homing pentapeptide CREKA (Cys-Arg-Glu-Lys-Ala) (DSPE-PEG-CREKA) to encapsulate a platelet inhibitor of ticagrelor (Tic), affording a multistimuli-responsive nanosystem (DPC@ICD-Gd-Tic). The nanosystem with completely quenching fluorescence could specifically target the tumor-associated platelets and showed pH/reduction/NIR light-responsive drug release, which simultaneously resulting in dis-assembly of nanoparticle and fluorescence recovery, enabling the drug delivery visualization in tumor in situ via activatable NIR fluorescence/MR bimodal imaging. Finally, DPC@ICD-Gd-Tic further integrated the photoinduced hyperthermia and platelet function inhibitor to achieve synergistic anticancer therapy, leading to ablation of primary tumor cells and effectively suppressed their distant metastasis. The number of lung metastases in 4T1 tumor bearing mice was reduced by about 90%, and the size of tumor was reduced by about 70%, while half of the mouse was completely cured by this smart nanosystem.

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Thermal and Photo Stability of Glutathione-Capped Cadmium Telluride Quantum Dots

Abstract: Glutathione-capped CdTe particles can be stored as dried nanoparticles for extended periods of time, enhancing their viability in biomedicine, biological labeling and cancer marker targeting.

Cited by 4 publications

References 8 publications

Preparation of chitin‐CdTe quantum dots films and antibacterial effect on Staphylococcus aureus and Pseudomonas aeruginosa

Preparation of chitin‐CdTe quantum dots films and antibacterial effect on Staphylococcus aureus and Pseudomonas aeruginosa

Physico-Chemical Properties of CdTe/Glutathione Quantum Dots Obtained by Microwave Irradiation for Use in Monoclonal Antibody and Biomarker Testing

Anti-Tumor Metastasis via Platelet Inhibitor Combined with Photothermal Therapy under Activatable Fluorescence/Magnetic Resonance Bimodal Imaging Guidance

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