Thermal and photochemical nitric oxide release from S-nitrosothiols incorporated in Pluronic F127 gel: potential uses for local and controlled nitric oxide release

Shishido, Sı́lvia Mika; Seabra, Amedea B.; Loh, Watson; Oliveira, Marcelo Ganzarolli de

doi:10.1016/s0142-9612(03)00153-4

Cited by 190 publications

(207 citation statements)

References 64 publications

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“…This result is in agreement with previously reported data. 57,64,71 The SGT as measured by DSC agreed with those measured with the inverted tube method. Figure 8A also shows an endothermic peak obtained for the pure 16% F127 solution.…”

Section: Thermal Analysis Of Thermo-sensitive F127 Systemsupporting

confidence: 68%

“…In our study, an easier and safer way to reduce the drug release rate was found to meet long-term treatment needs for certain diseases, such as localized injection of certain antitumor drugs in cancer therapy. The adding of liposomal drug to thermoreversible hydrogel can not only avoid the potential toxicity of greater amounts of copolymer (usually reported for above 20% F127 gel formulation), 47,57,60,63,64 but also provide higher drug loading (about 1020 µg/mL, determined in our experiment) than that possible with copolymer micelle gel alone (about 430 µg/mL, determined in our experiment). Potentially, the drug dose could be flexibly adjusted according to therapeutic needs for different individual patients and different disease states, simply by dispersing different liposome concentrations in gels.…”

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confidence: 48%

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Thermoreversible Pluronic® F127-based hydrogel containing liposomes for the controlled delivery of paclitaxel: in vitro drug release, cell cytotoxicity, and uptake studies

Nie¹,

Hsiao²,

Pan³

et al. 2011

IJN

119

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Purpose To develop an in situ gel system comprising liposome-containing paclitaxel (PTX) dispersed within the thermoreversible gel (Pluronic ® F127 gel) for controlled release and improved antitumor drug efficiency. Methods The dialysis membrane and membrane-less diffusion method were used to investigate the in vitro drug release behavior. Differential scanning calorimetry (DSC) thermal analysis was used to investigate the “micellization” and “sol/gel transition” process of in situ gel systems. In vitro cytotoxicity and drug uptake in KB cancer cells were determined by MTT, intercellular drug concentration, and fluorescence intensity assay. Results The in vitro release experiment performed with a dialysis membrane model showed that the liposomal gel exhibited the longest drug-release period compared with liposome, general gel, and commercial formulation Taxol ® . This effect is presumably due to the increased viscosity of liposomal gel, which has the effect of creating a drug reservoir. Both drug and gel release from the in situ gel system operated under zero-order kinetics and showed a correlation of release of PTX with gel, indicating a predominating release mechanism of the erosion type. Dispersing liposomes into the gel replaced larger gel itself for achieving the same gel dissolution rate. Both the critical micelle temperature and the sol/gel temperature, detected by DSC thermal analysis, were shifted to lower temperatures by adding liposomes. The extent of the shifts depended on the amount of embedded liposomes. MTT assay and drug uptake studies showed that the treatment with PTX-loaded liposomal 18% Pluronic F127 yielded cytotoxicities, intercellular fluorescence intensity, and drug concentration in KB cells much higher than that of conventional liposome, while blank liposomal 18% Pluronic F127 gel was far less than the Cremophor EL ® vehicle and empty liposomes. Conclusions A thermosensitive hydrogel with embedded liposome is a promising carrier for hydrophobic anticancer agents, to be used in parenteral formulations for treating local cancers.

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Section: Thermal Analysis Of Thermo-sensitive F127 Systemsupporting

confidence: 68%

mentioning

confidence: 48%

Thermoreversible Pluronic® F127-based hydrogel containing liposomes for the controlled delivery of paclitaxel: in vitro drug release, cell cytotoxicity, and uptake studies

Nie¹,

Hsiao²,

Pan³

et al. 2011

IJN

119

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“…progressively increase at lower rates, for both temperatures. A sustained NO release is observed for at least 10 h. The NO-release profile increased with the increase of the temperature, since the stability of this NO donor is dependent on the temperature, as expected [25][26][27]. Initial rates of NO released were calculated from the kinetic curves of Figure 2.…”

Section: No Release Profile From S-nitroso-msa-containing Chitosan Namentioning

confidence: 87%

“…The kinetics curves were monitored at 28 and 37 °C for 24 h. The amount of NO released was calculated from the amount of S-nitroso-MSA decomposed, as previous described [25,26]. The initial rates of NO release through S-nitroso-MSA decomposition were determined through linear regression of the curve slopes, as previous described [27].…”

Section: Kinetics Free No Release From S-nitroso-msa-chitosan/tpp Nanmentioning

confidence: 99%

Nitric oxide-releasing polymeric nanoparticles againstTrypanosoma cruzi

Seabra

Kitice

Pelegrino

et al. 2015

J. Phys.: Conf. Ser.

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“…Shishido et al [71] developed F127 hydrogel with the incorporation of NO donor GSNO and S-nitroso-N-acetylcysteine (SNAC), which retained a fluidic status at refrigerator temperature (∼5°C) and showed a temperature response as rigid semisolid clear gels in the body (∼37°C). The resultant hydrogels could release NO through thermal and photochemical decomposition.…”

Section: Hydrogelsmentioning

confidence: 99%

Modulated nitric oxide delivery in three-dimensional biomaterials for vascular functionality

et al. 2017

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Nitric oxide (NO) acts a pivotal role in regulating various physiological processes of vasodilation, platelet aggregation, and vascular smooth muscle cell mitogenesis and proliferation. This makes NO a promising candidate for the treatment of cardiovascular problems like hypertension and vascular stenosis. However, the high reactivity of NO poses an issue for effective NO delivery. To overcome this limitation, recent developments on three-dimensional (3D) materials have been explored with either physical or chemical incorporation of NO releasing donors, to provide spatiotemporal control over NO-signaling pathways in blood vessels. Here, we offer an overview on the current efforts, and propose future perspectives for precise regulation on NO delivery in advanced 3D materials toward proper vascular functionality.

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Thermal and photochemical nitric oxide release from S-nitrosothiols incorporated in Pluronic F127 gel: potential uses for local and controlled nitric oxide release

Cited by 190 publications

References 64 publications

Thermoreversible Pluronic® F127-based hydrogel containing liposomes for the controlled delivery of paclitaxel: in vitro drug release, cell cytotoxicity, and uptake studies

Thermoreversible Pluronic® F127-based hydrogel containing liposomes for the controlled delivery of paclitaxel: in vitro drug release, cell cytotoxicity, and uptake studies

Nitric oxide-releasing polymeric nanoparticles againstTrypanosoma cruzi

Modulated nitric oxide delivery in three-dimensional biomaterials for vascular functionality

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Thermal and photochemical nitric oxide release from S-nitrosothiols incorporated in Pluronic F127 gel: potential uses for local and controlled nitric oxide release

Cited by 190 publications

References 64 publications

Thermoreversible Pluronic&reg; F127-based hydrogel containing liposomes for the controlled delivery of paclitaxel: in vitro drug release, cell cytotoxicity, and uptake studies

Thermoreversible Pluronic&reg; F127-based hydrogel containing liposomes for the controlled delivery of paclitaxel: in vitro drug release, cell cytotoxicity, and uptake studies

Nitric oxide-releasing polymeric nanoparticles againstTrypanosoma cruzi

Modulated nitric oxide delivery in three-dimensional biomaterials for vascular functionality

Contact Info

Product

Resources

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Thermoreversible Pluronic® F127-based hydrogel containing liposomes for the controlled delivery of paclitaxel: in vitro drug release, cell cytotoxicity, and uptake studies

Thermoreversible Pluronic® F127-based hydrogel containing liposomes for the controlled delivery of paclitaxel: in vitro drug release, cell cytotoxicity, and uptake studies