Thermal and Physico-Mechanical Characterizations of Thromboresistant Polyurethane Films

Abstract

Hemocompatibility remains a challenge for injectable and/or implantable medical devices, and thromboresistant coatings appear to be one of the most attractive methods to down-regulate the unwanted enzymatic reactions that promote the formation of blood clots. Among all polymeric materials, polyurethanes (PUs) are a class of biomaterials with excellent biocompatibility and bioinertness that are suitable for the use of thromboresistant coatings. In this work, we investigated the thermal and physico-mechanical behaviors of ester-based and ether-based PU films for potential uses in thromboresistant coatings. Our results show that poly(ester urethane) and poly(ether urethane) films exhibited characteristic peaks corresponding to their molecular configurations. Thermal characterizations suggest a two-step decomposition process for the poly(ether urethane) films. Physico-mechanical characterizations show that the surfaces of the PU films were hydrophobic with minimal weight changes in physiological conditions over 14 days. All PU films exhibited high tensile strength and large elongation to failure, attributed to their semi-crystalline structure. Finally, the in vitro clotting assays confirmed their thromboresistance with approximately 1000-fold increase in contact time with human blood plasma as compared to the glass control. Our work correlates the structure-property relationships of PU films with their excellent thromboresistant ability.

Thermally stable poly(urethane‐imide)s with enhanced hydrophilicity for waterproof‐breathable textile coatings

“…All the PUIs exhibit broad halos at 2θ ~ 6° and 2θ ~ 20–21°, however, the width of these diffraction peaks is narrower as compared to PU, which is indicative of a slightly higher degree of order. The presence of a small peak at 2θ ~ 23° in the diffraction pattern of PUI46 indicates partial crystallization of soft segments associated with PEG 43,44 . This crystallization of the PEG‐based soft segment is also evidenced as a distinct melting peak at 20 °C in the DSC trace of PUI46 (Figure 7).…”

“…The presence of a small peak at 2θ ~23 in the diffraction pattern of PUI46 indicates partial crystallization of soft segments associated with PEG. 43,44 This crystallization of the PEG-based soft segment is also evidenced as a distinct melting peak at 20 C in the DSC trace of PUI46 (Figure 7).…”

High‐Performance Stretchable Strain Sensor Based on Ag Nanoparticles Sandwiched between Two 3D‐Printed Polyurethane Fibrous Textiles

“…It is obvious that the mass loss results from the decomposition of the TPU matrix. [ 25 ] The printed samples, TPU/Ag‐P1, TPU/Ag‐P2, and TPU/Ag‐P3 have Ag NP concentrations of 2.0, 4.3, and 7.5 wt%, respectively. As expected, the conductive network was constructed in all the printed samples (Figure 3b).…”

Inhibition of Platelet Adhesion from Surface Modified Polyurethane Membranes

“…In addition to the surface chemical nature and ionic charges, surface wettability of PU coatings can be used as an effective surface modifier [ 6 ]. In a study, soybean-derived Phosphatidylcholine (PC) modified PU coatings were prepared by dipping PU coatings in PC containing PU solutions followed by solvent evaporation [ 26 ].…”

“…In our previous work [ 4 ], we have provided a perspective on the applications of engineering membranes, including drug-eluting materials and surface modified polymeric and/or non-polymeric coatings on medical implants to improve hemocompatibility. In particular, our original research work indicated that polyurethane membranes slowed down blood coagulation by 1000-fold as compared to the glass control surfaces [ 6 ]. As a continuous effort to investigate the hemocompatibility of polymeric membranes, while providing an overview of current methods performed on the in vitro platelet adhesion assays, we review research works done in the field with modified polyurethane membranes.…”