Thermal behavior and mechanical properties of physically crosslinked PVA/Gelatin hydrogels

Liu, Yurong; Geever, Luke M.; Kennedy, James E.; Higginbotham, Clement L.; Cahill, Paul A.; McGuinness, Garrett B.

doi:10.1016/j.jmbbm.2009.07.001

Cited by 178 publications

(102 citation statements)

References 31 publications

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“…The PVA also offers flexibility, toughness, transparency as well as lower cost, and for this reason, PVA has also been used as biodegradable film production [15], including blended with proteins of various sources, such as PVA/wheat [16] and PVA/gelatin [17].…”

Section: Introductionmentioning

confidence: 99%

Designing polyethylene glycol (PEG) – plasticized membranes of poly(vinyl alcohol-g-methyl methacrylate) and investigation of water sorption and blood compatibility behaviors

Jain

Bajpai

2012

Designed Monomers and Polymers

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Polyethylene glycol (PEG)-based semi-IPNs have been widely used as hydrogel matrices in tissue engineering applications because of their inherent hydrophilicity and biocompatibility. Today, synthetic scaffolds are being widely used in tissue engineering and allied applications because they offer the ability to precisely control the mechanical properties, morphology, and blood compatibility of the materials. In this regard, an attempt has been made to develop scaffolds membranes by judiciously combining PEG, polyvinyl alcohol, and polymethyl methacrylate. The so prepared hydrogel membranes were undertaken for structural, morphological, and thermal characterization using FTIR, scanning electron microscope (SEM), and DSC techniques, respectively. The hydrogel films were investigated for water sorption capacity under various experimental conditions such as changing chemical composition of the membrane, different pH, and temperature of the swelling media and varying simulated biological fluids. The hydrogel membranes were also studied for their catholicity and in vitro blood compatibility property by following several tests such as blood clot formation, percent haemolysis, and protein adsorption.

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Section: Introductionmentioning

confidence: 99%

Designing polyethylene glycol (PEG) – plasticized membranes of poly(vinyl alcohol-g-methyl methacrylate) and investigation of water sorption and blood compatibility behaviors

Jain

Bajpai

2012

Designed Monomers and Polymers

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“…[32,33] Therefore, the degree of crystallinity can be quantitatively estimated by the enthalpy of melting, which is the third relaxation in the temperature range of 200-250 C as reported by Liu et al. [6] The crystallinity degree of PVA hydrogel was calculated as 25.3 AE 0.2 % whereas the crystallinity degree of native PVA was about 50%. Therefore, the crosslinking procedure drastically decreased the degree of crystallinity and, as a consequence, the brittleness of the material, which should be avoid for the foreseen application being the accomodative action one of the most important cartilage characteristics.…”

Section: Hydrogel Thermal Stabilitymentioning

confidence: 96%

States of water, surface and rheological characterisation of a new biohydrogel as articular cartilage substitute

Leone

Bidini²,

Lamponi

et al. 2013

Polymers for Advanced Techs

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PVA based hydrogel was synthesised using, as crosslinking agent, trisodium trimetaphosphate (STMP) and its morphology was modified inducing a microporous structure to obtain potential substitutes for cartilage tissue. The hydrogel was characterised by Infrared Spectroscopy combined with Time of flight mass spectrometry (ToF-SIMS) that confirmed the successful occurrence of crosslinking reaction, the hyphotised crosslinking arm and its homogeneous distribution. The mechanical spectra of the fully hydrated samples confirmed covalently crosslinked systems with a rheological behaviour similar to that of tibial cartilage. Further analysis in terms of water content measurements, thermal stability and cytotoxicity confirmed the applicability of such a hydrogel as cartilage substitute

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“…A small shoulder at 1,138.8 cm -1 can be attributed to stretching of C-O (crystalline sequence of PVA). The peaks at 1,084 cm -1 in PVA/BC composite, shifted to 1,070 cm -1 in PVA/BC/CTS composite can be attributed to stretching of C=O and bending of OH (amorphous sequence of PVA), 917 cm -1 shifted to 920 cm -1 in PVA/ BC/CTS to CH 2 rocking, and the peak around 826 cm -1 to C-C stretching [27,28]. The sharp peak at 1,054.8 cm -1 and shoulder at 1,033 cm -1 present in the PVA/BC spectra can be assigned to the -C-O-C-in glycosidic bonds, respectively to C-O stretching vibration of aliphatic primary and secondary alcohols in cellulose [29,30].…”

Section: Film Characterizationmentioning

confidence: 99%

Biodegradation Behavior of Composite Films with Poly (Vinyl Alcohol) Matrix

et al. 2011

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The main objective of this study was to develop biodegradable, composite materials, based on poly (vinyl alcohol), bacterial cellulose and chitosan for possible application in packaging industry. Two composite materials were prepared, one containing poly (vinyl alcohol) (PVA) and bacterial cellulose (BC), named PVA/BC, and the other containing PVA, BC but also chitosan (CTS), named PVA/BC/CTS. The biodegradation behavior was studied in a fed-batch bioreactor, in aerobic and anaerobic conditions, using activated sludge. Biodegradation tests were based on weight loss measurements. Structural changes were confirmed by Fourier transform infrared spectroscopy (FTIR) and the morphological ones by scanning electron microscopy (SEM). After 4 weeks, the biodegradation experiments have shown a relative high degradation of the PVA/BC/CTS film compared with the PVA/BC one. These results were confirmed by spectral analysis and also by SEM images. Besides, the SEM images revealed that biodegradation occurs also inside the composite materials, not only on the surface.

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Thermal behavior and mechanical properties of physically crosslinked PVA/Gelatin hydrogels

Cited by 178 publications

References 31 publications

Designing polyethylene glycol (PEG) – plasticized membranes of poly(vinyl alcohol-g-methyl methacrylate) and investigation of water sorption and blood compatibility behaviors

Designing polyethylene glycol (PEG) – plasticized membranes of poly(vinyl alcohol-g-methyl methacrylate) and investigation of water sorption and blood compatibility behaviors

States of water, surface and rheological characterisation of a new biohydrogel as articular cartilage substitute

Biodegradation Behavior of Composite Films with Poly (Vinyl Alcohol) Matrix

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