Thermal behavior of griseofulvin: fusion, sublimation and vaporization

Blokhina, Svetlana V.; Sharapova, Angelica; Ol’khovich, Marina V.; Perlovich, German L.

doi:10.1007/s10973-022-11329-0

Cited by 2 publications

(2 citation statements)

References 26 publications

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“…A thorough description of this method is presented in works. 18,19 The gas carrier was supplied from the cylinder through a pressure reducer to a column filled with silica gel to remove residual moisture. The stability of the gas flow with a precision over 0.1% was maintained by using an MKS type 1259CC-00050SU mass flow controller.…”

Section: Transpiration Methodmentioning

confidence: 99%

“…The experimental measurement of the saturated vapor pressure of niclosamide was conducted by the transpiration method in a carrier gas flow with dried nitrogen as the carrier gas. A thorough description of this method is presented in works. , The gas carrier was supplied from the cylinder through a pressure reducer to a column filled with silica gel to remove residual moisture. The stability of the gas flow with a precision over 0.1% was maintained by using an MKS type 1259CC-00050SU mass flow controller.…”

Section: Experimental Partmentioning

confidence: 99%

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Sublimation and Vaporization Enthalpies of Niclosamide: Application of Transpiration Method and Thermogravimetric Analysis

Blokhina,

Sharapova,

Ol’khovich

2023

J. Chem. Eng. Data

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The thermodynamic functions of sublimation and vaporization of the drug niclosamide were determined by several experimental methods. The vapor pressure of niclosamide was measured at different temperatures in the crystalline phase by the transpiration method. The drug sublimation standard molar enthalpy, entropy, and Gibbs free energy were derived from these data. The vaporization enthalpy was determined by thermogravimetric analysis. The fusion temperature and enthalpy of the compound were also measured. The enthalpies of sublimation, vaporization, and fusion were adjusted to the reference temperature using the heat capacity values experimentally obtained in this work. By combining the vaporization and fusion enthalpies obtained by thermogravimetry and differential scanning calorimetry, the standard molar enthalpy of sublimation was derived (166.7 ± 4.5) kJ•mol −1 , which was 4% higher than the value determined by the transpiration method (160.3 ± 1.9) kJ•mol −1 .

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Section: Transpiration Methodmentioning

confidence: 99%

Section: Experimental Partmentioning

confidence: 99%