Thermal behavior of some antihistamines

Perpétuo, Glauco Lini; Gálico, Diogo A.; Fugita, R. A.; Castro, Ricardo A. E.; Eusébio, M. Ermelinda S.; Treu-Filho, Oswaldo; Silva, A. C M; Bannach, Gilbert

doi:10.1007/s10973-012-2247-0

Cited by 34 publications

(18 citation statements)

References 20 publications

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“…Thermal methods of analysis are widely used for studying thermal behavior [3][4][5][6], polymorphism [3], solidstate reactions [7,8], drug formulations [9,10], purity [11], gaseous decomposition products [12] and other properties of solid compounds used in pharmaceutical industry [13]. Theoretical calculations combined with experimental infrared are very useful to understand the structure of pharmaceuticals [4][5][6][7][8].…”

Section: Figure 1 Structural Formula Of Amoxicillinmentioning

confidence: 99%

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Solid state thermal and spectroscopic studies on the antibiotic amoxicillin trihydrate

Gálico

Guerra

Legendre

et al. 2013

Braz. J. Therm. Anal.

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Thermogravimetry (TG), differential thermal analysis (DTA), differential scanning calorimetry (DSC) and Fourier transformed infrared spectroscopy (IR) were used to study amoxicillin trihydrate. The thermal behavior and physical properties of the studied compound were established and coupled TG-IR analyses were used to suggest some decomposition products. In this investigation, quantum chemical approach was used to determine the molecular structures using Becke three-parameter hybrid method and the Lee-Yang-Par (LYP) correlation functional. The performed molecular calculations in this work were done using the Gaussian 09 routine. The theoretical calculations helped us interpret the IR spectra, which supply structural and physicochemical information.

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Section: Figure 1 Structural Formula Of Amoxicillinmentioning

confidence: 99%

“…Theoretical calculations combined with experimental infrared are very useful to understand the structure of pharmaceuticals [4][5][6][7][8].…”

Section: Figure 1 Structural Formula Of Amoxicillinmentioning

confidence: 99%

Solid state thermal and spectroscopic studies on the antibiotic amoxicillin trihydrate

Gálico

Guerra

Legendre

et al. 2013

Braz. J. Therm. Anal.

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“…However, thermal analysis techniques are very important as an analytical tool which give an information about the effect of heat on the compounds. These techniques allow evaluation of the thermal stabilities of the compounds and consider a useful tool to obtain the kinetic parameters of solid-state reactions [7][8][9]. Many methods have been reported.…”

Section: Introductionmentioning

confidence: 99%

Complexes of Schiff base of benzopyran-4-one derivative

Abdel-Kader

Amin

El-Ansary

2015

J Therm Anal Calorim

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New metal complexes of Schiff base (L) prepared from condensation reaction of 2-aminopyridine and 6-formyl-7-hydroxy-5-methoxy-2-methylbenzopyran-4-one with metal ions; Mn(II), Co(II), Ni(II) and Cu(II) are synthesized. Different analysis tools such as elemental analyses, FTIR, thermal analyses, conductivity, mass spectrometry, electronic spectra and magnetic susceptibility measurements are all used to elucidate the structures of the newly prepared metal complexes. The IR spectral data suggested that the ligand behaves as a monobasic bidentate ligand toward the central metal ion with ON donor atoms. The thermal decomposition kinetics of all complexes was estimated by Coats-Redfern. Ni-L and Co-L complexes were selected to study their thermal decomposition under non-isothermal conditions using Flynn-Wall-Ozawa and Starink methods at different three heating rates (5, 10 and 15°C min -1 ). The values of the activation energy (E) obtained by the all methods are in good agreement. All complexes are thermally stable as reflected from the high value of their activation energies. Ni-L complex has the highest thermal stability, and Mn-L complex has the lowest one indicating that Mn-L complex has fast rate of successive decomposition. The Schiff base L, Cu-L and Mn-L compounds were screened for in vitro cytotoxicity against normal standard fibroblast cells (3T3) using MTT assay. Among these compounds, Mn-L complex enhanced growth inhibition and cell death in a concentrationdependent manner for the standard fibroblast cells (3T3). Mn-L complex was then subjected against four human cancer cell lines; human hepatocellular carcinoma (Huh-7), human Hepatoblastoma (Hep G2) and human cervical cancer cells (HeLa & HeLa-Fas) for anticancer activity. Results indicate that Mn-L complex may be useful leads for anticancer drug development in the future.

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“…Thermal methods of analysis are widely used to investigate polymorphism, thermal decomposition, thermal stability, solid-state reactions, drug formulations, purity, reaction kinetics, evolved gas analysis by coupled TG-FTIR, and other properties of solid compounds used in the pharmaceutical industry. Due to the numerous studies directly and indirectly involved with these issues, it is essential to have a complete understanding of the properties of pharmaceutical materials [10][11][12][13][14][15].…”

Section: Introductionmentioning

confidence: 99%

Synthesis, Thermal and Spectroscopic Studies of Lithium Salt of Naproxen.

Gálico

Nova

Guerra

et al. 2015

Braz. J. Therm. Anal.

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A new lithium salt was synthesized and characterized. The stoichiometry of the salt was LiNap . 1H 2 O. The salt was thermally stable until 260 °C and 275 °C in air and nitrogen atmospheres, respectively, and did not melt until decomposition. The salt was highly crystalline and the crystal had a prismatic form. A spectroscopic study of the compound was performed, which covered the UV, Vis, NIR and MIR regions. The fluorescence studies showed that the salt emitted at 356 nm when excited at 236 or 264 nm. This emission was assigned to the first singlet excited state to the singlet ground level state of the compound.

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Thermal behavior of some antihistamines

Cited by 34 publications

References 20 publications

Solid state thermal and spectroscopic studies on the antibiotic amoxicillin trihydrate

Solid state thermal and spectroscopic studies on the antibiotic amoxicillin trihydrate

Complexes of Schiff base of benzopyran-4-one derivative

Synthesis, Thermal and Spectroscopic Studies of Lithium Salt of Naproxen.

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