Thermal behaviour of some new complexes with decaaza bismacrocyclic ligand as potential antimicrobial species

Bucur, Cristina; Badea, Mihaela; Calu, Larisa; Marinescu, Dana; Grecu, Maria Nicoleta; Stănică, Nicolae; Chifiriuc, Mariana Carmen; Olar, Rodica

doi:10.1007/s10973-012-2199-4

Cited by 4 publications

(1 citation statement)

References 27 publications

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“…Moreover, a series of complexes with bismacrocycle (bmc) ligands [M 2 (bmc1)](CH 3 COO) 4 nH 2 O ( 53 ) (M: Ni, Cu, Zn; bmc1: 1,2-bis( N , N -1,3,6,9,12-pentaazacyclotridecane)-benzene) were designed as antimicrobials and Zn(II) complex exhibit ability to inhibit the S. aureus , B. subtilis , E. faecalis , K. pneumoniae , E. coli , E. cloacae , P. aeruginosa and C. krusei adherence on inert substratum [ 128 ].…”

Section: Complexes With Antibiofilm Activitymentioning

confidence: 99%

Metal Complexes—A Promising Approach to Target Biofilm Associated Infections

2022

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Microbial biofilms are represented by sessile microbial communities with modified gene expression and phenotype, adhered to a surface and embedded in a matrix of self-produced extracellular polymeric substances (EPS). Microbial biofilms can develop on both prosthetic devices and tissues, generating chronic and persistent infections that cannot be eradicated with classical organic-based antimicrobials, because of their increased tolerance to antimicrobials and the host immune system. Several complexes based mostly on 3D ions have shown promising potential for fighting biofilm-associated infections, due to their large spectrum antimicrobial and anti-biofilm activity. The literature usually reports species containing Mn(II), Ni(II), Co(II), Cu(II) or Zn(II) and a large variety of multidentate ligands with chelating properties such as antibiotics, Schiff bases, biguanides, N-based macrocyclic and fused rings derivatives. This review presents the progress in the development of such species and their anti-biofilm activity, as well as the contribution of biomaterials science to incorporate these complexes in composite platforms for reducing the negative impact of medical biofilms.

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Section: Complexes With Antibiofilm Activitymentioning

confidence: 99%