Thermal characterization of highly exothermic flash chemistry in a continuous flow calorimeter

Abstract

A key parameter for reactor design and safety evaluation is the reaction enthalpy (ΔHr). Flash chemistry is a field of chemical synthesis where fast reactions are performed in a precise...

Rapid production of the anaesthetic mepivacaine through continuous, portable technology

“…A continuous flow setup, with its highly efficient heat transfer and smaller reactor volumes, could offer a practical solution and could be tested with N -methylpipecolinate ( 4b ). 30–33…”

“…A continuous flow setup, with its highly efficient heat transfer and smaller reactor volumes, could offer a practical solution and could be tested with N-methylpipecolinate (4b). [30][31][32][33] With our system, the use of hexane for the lithiation step (entries 1 and 2, Table 3) enabled such a reaction to be carried out at room temperature; however, the required solvent exchange from hexane to 2-MeTHF to carry out the coupling of the Li-amide with 4b appeared problematic for its transposition to flow. In batch, this is a straightforward task that only requires evaporation and subsequent solvent addition.…”

Thermokinetic analyses of metal-sensitive reactions in a ceramic flow calorimeter

“…The overall layout of the ceramic flow calorimeter is a continuation of our previous work 36 and uses the same measurement principle, overall sensor layout, and heat balance calculations. Even though the inner geometry of the reactor plate is not new, we present here the investigation of the mixing behavior via fluid simulations, similar to the work of Fu et al , 37 as well as residence time measurements. This was carried out to gauge both mixing properties and possible reaction times possible in the calorimeter.…”

Design and characterization of a flow reaction calorimeter based on FlowPlate® Lab and Peltier elements

“…10 Concerning calorimetry using microreactors, three basic concepts prevail for technical realization: optical measurements using infrared cameras, [11][12][13][14][15] energy balance based on temperature measurements, 9,16 and heat flux measurements using the thermoelectric effect. [17][18][19][20][21][22][23][24][25][26] Although several flow calorimeters have been developed using these concepts or combinations of them, only a few are commercially available. An example for a commercially available flow calorimeter is provided by Fluitec, Neftenbach, Switzerland.…”