The acoustic environment in an urban dwelling is a key factor in human health, especially in megacities, where there are high levels of traffic noise. This study investigated the effects of various socio-economic indicators (gender, age, roadside residence, average daily time at home) on the subjective evaluation of residential acoustic environments, employing a series of questionnaire surveys and in-depth interviews in two Chinese megacities (Chongqing and Guangzhou). The findings indicate that residents in Chongqing, a typical mountainous city, are less satisfied with their acoustic environment than those in Guangzhou, a city built on a plain. However, there were no significant differences between residents in the two Chinese megacities in terms of their perspectives on their thermal, humid or luminous environments or noise-related health symptoms. Regarding perceptions of acoustic environments, there were significant differences between residents in the mountainous city and the plain city, as well as those in roadside and non-roadside homes, but no significant differences were identified between the views of men and women or the young and the old, and time spent at home appeared to have no impact. Moreover, age and average daily time spent at home are likely to be associated with noise-related health symptoms.