The worldwide growing need of cotton but its lower production has boosted the production of regenerated cellulosic fibers. This work compares the thermal comfort and mechanical properties of bamboo rayon fiber blends with cotton and other regenerated fibers. So, bamboo rayon fibers were blended with cotton, tencel lyocell, modal rayon, and viscose rayon. One-hundred-percent pure fabrics of bamboo rayon, cotton, tencel lyocell, modal rayon, and viscose rayon were made. Also, 50:50 blends of bamboo rayon with cotton, tencel lyocell, modal rayon, and viscose rayon were prepared. Plain-woven fabrics were made by using yarns of 20 tex. The thermal comfort and mechanical properties were analyzed. It is found that 100% tencel lyocell fabrics give higher mechanical and comfort properties. Similarly, bamboo rayon:tencel lyocell (50:50)-blended fabric gives better thermal comfort and mechanical properties than bamboo rayon:cotton-, bamboo rayon:modal rayon-, and bamboo rayon:viscose rayon-blended fabrics. Keywords cotton, regenerated fibers, bamboo fiber, comfort properties, mechanical properties Almost two thirds of the surface of Earth is covered up with water. Of this water, 2.05% is frozen water, 97.4% is salty seawater, and the fresh water that is healthy enough for plant, animal and human consumption is only 0.65% (Krenkel, 2012). Among various crops, cotton is one of the thirstiest and is responsible for damaging the freshwater ecosystems both locally and globally. Cotton is a major natural fiber consumed in the apparel industry due to its excellent properties