Thermal damage to red cells

Baar, S.; Arrowsmith, D. J.

doi:10.1136/jcp.23.7.572

Cited by 24 publications

(11 citation statements)

References 11 publications

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“…It has been suggested that it represents the distribution of susceptibilities of a population of cells to the damaging agent. Possibly this variation is one of age, comparable with the age variation which can be demonstrated in a population of red cells (Baar and Arrowsmith, 1970), the young cells being those which are easily inhibited and the oldest cells being the most resistant to damage. The greater sensitivity to damage by ultrasound of the processes involved in sulphate uptake is of particular interest and may be a more specific effect.…”

Section: Discussionmentioning

confidence: 58%

Some effects of ultrasound on guinea-pig ear skin

Carney

Lawrence

Ricketts

1972

Occupational and Environmental Medicine

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. (1972). Brit. J. industr. Med., 29, 214-220. Some effects of ultrasound on guinea-pig ear skin. Slices of guinea-pig ear skin were irradiated with ultrasound of frequency 3 MHz for 30 seconds at various power densities. After irradiation the specimens were incubated on a nutrient medium for 24 hours. Measurements of the uptake of 32PO43-and 35S042-, skin cell respiration, and dehydrogenase activity were then made. In each case a graded inhibition with increasing power density was observed. These inhibitions were attributed to thermal damage of the skin cells, a view consistent with the histological appearance of the specimens.Ultrasound has long been used in the laboratory for cleaning apparatus and for disrupting bacterial cells and is also finding increased application in industry. Wells (1970) has reviewed the extensive use now made of ultrasonic devices in the medical field. Macintosh and Davey (1970) reported the finding of increased numbers of abnormal chromosomes in human white cells exposed to ultrasound from a fetal pulse detector. It is apparent that greater knowledge of the effects of ultrasound on living tissues is very desirable, and the present study is an attempt to define conditions under which such radiation affects some of the metabolic functions of skin. Materials and methodsThe apparatus consisted of a continuous wave oscillator at 3 MHz driving a piezoelectric crystal sealed into a water-cooled probe terminated by a thin polythene film. For calibration the probe was placed in the water-bath of an ultrasonic balance, and the sound pressure was balanced by riders of known weight (67 mg = 1 watt). The profile of the beam (see Fig. 1) had previously been determined (P. N. T. Wells, private communication) by a thermal method. The central portion only of the beam was used in exposing skin specimens and over this region the mean intensity was 81 % of the maximum intensity as illustrated (Fig. 1). The unit relative intensity was 4-88P, where P = total power in watts. As the specimens were exposed at an average relative intensity of 0 81, the power density was 3 95P W.cm-2.

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Section: Discussionmentioning

confidence: 58%

Some effects of ultrasound on guinea-pig ear skin

Carney

Lawrence

Ricketts

1972

Occupational and Environmental Medicine

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“…Echinocytosis, which is an indicator for morphological change is a characteristic of RBC thermal damage frequently used for this purpose. It was shown that one of the earliest morphological manifestations of RBC following heat injury is their transformation from disc to spherical shape [51].…”

Section: R T R T T K T R T Q R T (5)mentioning

confidence: 99%

The Effect of Laser Power on Photothermoacoustic Imaging of Blood Containing Gold Nanoparticles and Deoxygenation using a Frequency-Domain Phased Array Probe: An In-vitro Assay

Khosroshahi¹

2015

NSTOA

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“…Similar findings have been made in patients with burns (Arturson & Hjelm, 1966, 1969. Younger erythrocytes are more easily damaged by heat and burned patients have a cell population enriched in older erythrocytes (Baar & Arrowsmith, 1970 Arturson and M . Hjelm Baar, 1979).…”

Section: The Concentrations O J Hexosemonophosphates In Erythrocymentioning

confidence: 99%

Concentration of Adenine Nucleotides and Glycolytic Intermediates in Erythrocytes, Liver and Muscle Tissue in Rats After Thermal Injury

Arturson¹,

Hjelm²

1984

Scandinavian Journal of Plastic and Reconstructive Surgery

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A 40% total body scald burn was produced in mature rats. An immediate decrease of the metabolic rate was followed by a hypermetabolic response similar to that described in human beings following thermal injury. The amounts of adenine nucleotides and hexosemonophosphates were monitored in three types of cells: erythrocytes (which lack mitochondria), skeletal muscle cells (which to a certain extent can rely on an increased glycolysis for their increased energy supply) and liver cells (which are sensitive to hypoxia and have a great need of energy in the post-traumatic period). Only in the liver did the energy charge derived from the individual concentrations of adenine nucleotides change significantly, but remained virtually constant in muscle cells and erythrocytes despite a change in total oxygen consumption, from minus 85% (in the early phase) to plus 30% (in the later phase) of the expected value. Altered energy metabolism in liver and muscle tissues is related to wound healing, whereas the biochemical changes in erythrocytes is related to the degree of haemolysis of younger cells induced by the thermal injury.

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Thermal damage to red cells

Cited by 24 publications

References 11 publications

Some effects of ultrasound on guinea-pig ear skin

Some effects of ultrasound on guinea-pig ear skin

The Effect of Laser Power on Photothermoacoustic Imaging of Blood Containing Gold Nanoparticles and Deoxygenation using a Frequency-Domain Phased Array Probe: An In-vitro Assay

Concentration of Adenine Nucleotides and Glycolytic Intermediates in Erythrocytes, Liver and Muscle Tissue in Rats After Thermal Injury

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