Thermal Decomposition of Ethyl Diazoacetate in Microtube Reactor: A Kinetics Study

Abstract

Ethyl diazoacetate (EDA) commonly experiences intensive decomposition as well as complex conversion concerning safety and efficiency. In this work, a careful kinetics study on the thermal decomposition of EDA was isothermally conducted in a microtube reactor to establish a mechanism-based kinetic model. The model parameters were well calibrated with experimental data including the yield of dimmers and the conversion of EDA, confirming the rationality of the proposed three-step reaction route. It allows the model to concisely describe the complex species transformations during EDA decomposition, which is unavailable for an apparent kinetic model. Considering an isothermal reaction system and the tolerance of EDA consumption by thermal decomposition, this work could help reveal the requirement on the kinetic characteristics of the desired catalytic reaction in which EDA is involved, as a reference on reaction process modeling and regulation.

Continuous Synthesis of Diazo Acetonitrile: From Experiments to Physical and Grey‐Box Modeling

“…These are the primary reactions taking place. The formed carbene can undergo numerous secondary reactions, forming dimers, oligomers, or an alcohol by the reaction with water molecules [37,38]. These reactions, due to growing complexity, are not considered here.…”

Theoretical studies to predict the utility of diazo esters in their reactions with 1,4-quinones: experimental validationviaa visible light driven metal free process

“…Among the diazo compounds, diazo esters are one of the most promising subclasses of compounds that have demonstrated remarkable applications in various reactions. 6,7 Initially, they were used extensively as precursors of metal carbenoids, when reacted with metal catalysts. 6 At times, they also afford carbenes by thermal heating or under UV light, after the liberation of N 2 ↑.…”

“…6 At times, they also afford carbenes by thermal heating or under UV light, after the liberation of N 2 ↑. 7 In later years, blue LEDs were widely used to generate carbenes (both singlet and triplet) from diazo esters, which were then used in various reactions such as CH- and XH-insertions, cyclopropane ring formation, cycloaddition, ylide formation, 1,2-migration, etc . 8 The preparation of diazo esters is straightforward and most of them (including the ones discussed here) are bench stable and safe to handle.…”