Thermal Degradation Processes of Aromatic Poly(Ether Sulfone) Random Copolymers Bearing Pendant Carboxyl Groups

Dattilo, Sandro; Puglisi, Concetto; Mirabella, Emanuele Francesco; Spina, Angela; Scamporrino, Andrea; Zampino, Daniela; Blanco, Ignazio; Cicala, Gianluca; Ognibene, Giulia; Mauro, Chiara Di; Samperi, Filippo

doi:10.3390/polym12081810

Cited by 12 publications

(2 citation statements)

References 39 publications

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“…As a result, polymeric amine counter ions stopped the sulfonic acid's negative charge, which is extremely susceptible to hydrolytic heat degradation. The breakdown of the polymer chain can be linked to progressive weight loss [44,46]. Because the large loss in weight of the sample is more frequently detected when the temperature breaches the barrier of 650 • C, the temperature at which the analysis was capped in this case, although some loss in the weight of the sample was recorded, was less significant.…”

Section: Tga Analysismentioning

confidence: 99%

Sulfonated Polyether Ketone Membranes Embedded with Nalidixic Acid—An Emerging Controlled Drug Releaser

Padinjarathil,

Vilasini,

Balasubramanian

et al. 2023

Polymers

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The effective administration of medication has advanced over decades, but the medical community still faces significant demand. Burst release and inadequate assimilation are major drawbacks that affect wound healing efficiency, leading to therapy failure. The widespread application of polymers in biomedical research is significant. The polyether ether ketone (PEEK) family is known for its biocompatibility, inertness, and semi-crystalline thermoplastic properties. In our present studies, we have chosen a member of this family, polyether ketone (PEK), to explore its role as a drug carrier. The PEK backbone was subjected to sulfonation to increase its hydrophilicity. The response surface methodology (RSM) was used to optimize the sulfonation process based on the time, degree of sulfonation, and temperature. The PEK polymer was sulfonated using sulfuric acid at 150 °C for 6 h; back titration was performed to quantify the degree of sulfonation, with 69% representing the maximum sulfonation. SPEK and nalidixic sodium salt were dissolved in dichloroacetic acid to create a thin membrane. The physiological and morphological properties were assessed for the SPEK membrane. The studies on drug release in distilled water and a simulated body fluid over the course of 24 h revealed a controlled, gradual increase in the release rate, correlating with a mathematical model and demonstrating the zero-order nature of the drug release. Hemolysis on the SPEK membrane revealed lower toxicity. The SPEK membrane’s biocompatibility was established using in vitro cytotoxicity tests on the Vero (IC50: 137.85 g/mL) cell lines. These results confirm that the SPEK membranes are suitable for sustained drug release.

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Section: Tga Analysismentioning

confidence: 99%

Sulfonated Polyether Ketone Membranes Embedded with Nalidixic Acid—An Emerging Controlled Drug Releaser

Padinjarathil,

Vilasini,

Balasubramanian

et al. 2023

Polymers

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“…To date, numerous condensation polymers, including multi-component liquid crystalline aromatic polyesters (LCPs), cationic polyacrylamide resins, copolymer type polycarbonates (PCs) [93], poly(aryl ether sulfone) [94], and P(HB-co-HV) [95][96][97], have been subjected to compositional analysis using THM-GC in the presence of TMAH. Among these papers, Sato et al used the THM-GC method for the compositional analysis of a biodegradable copolyester, P(HB-co-HV), with various ratios of the 3HV contents (ca.…”

Section: Thermally Assisted Hydrolysis and Methylation-gas Chromatogr...mentioning

confidence: 99%

Methods of Analyses for Biodegradable Polymers: A Review

Baidurah

2022

Polymers

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Biodegradable polymers are materials that can decompose through the action of various environmental microorganisms, such as bacteria and fungi, to form water and carbon dioxide. The biodegradability characteristics have led to a growing demand for the accurate and precise determination of the degraded polymer composition. With the advancements in analytical product development, various analytical methods are available and touted as practical and preferable methods of bioanalytical techniques, which enable the understanding of the complex composition of biopolymers such as polyhydroxyalkanoates and poly(lactic acid). The former part of this review discusses the definition and examples of biopolymers, followed by the theory and instrumentation of analytical methods applicable to the analysis of biopolymers, such as physical methods (SEM, TEM, weighing analytical balance, etc.), chromatographic methods (GC, THM-GC, SEC/GPC), spectroscopic methods (NMR, FTIR, XRD, XRF), respirometric methods, thermal methods (DSC, DTA, TGA), and meta-analysis. Special focus is given to the chromatographic methods, because this is the routine method of polymer analysis. The aim of this review is to focus on the recent developments in the field of biopolymer analysis and instrument application to analyse the various types of biopolymers.

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Kinetic study of the thermal and thermo-oxidative degradations of aromatic poly(ether sulfone) random copolymers bearing pendant carboxyl groups

Blanco

Cicala²,

Samperi³

et al. 2023

J Therm Anal Calorim

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Thermal Degradation Processes of Aromatic Poly(Ether Sulfone) Random Copolymers Bearing Pendant Carboxyl Groups

Cited by 12 publications

References 39 publications

Sulfonated Polyether Ketone Membranes Embedded with Nalidixic Acid—An Emerging Controlled Drug Releaser

Sulfonated Polyether Ketone Membranes Embedded with Nalidixic Acid—An Emerging Controlled Drug Releaser

Methods of Analyses for Biodegradable Polymers: A Review

Kinetic study of the thermal and thermo-oxidative degradations of aromatic poly(ether sulfone) random copolymers bearing pendant carboxyl groups

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