Thermal detection of cellular infiltrates in living atherosclerotic plaques: possible implications for plaque rupture and thrombosis

Casscells, Ward; Vaughn, William K.; McAllister, H.; Willerson, James T.; Hathorn, B.; David, Miriam; Krabach, Timothy N.; Bearman, Greg

doi:10.1016/s0140-6736(96)91684-0

Cited by 336 publications

(207 citation statements)

References 17 publications

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“…Ultrasound based "virtual histology" 81 , Raman spectroscopy 82 , thermography 83 near-infrared spectroscopy 84 or optical coherence tomography 85 86 , and a variety of molecular imaging strategies have all undergone development seeking to detect the inflammatory thin cap fibroatheroma, the type of plaque supposed to entail a high risk for a thrombotic event based on the pathological observations from the last century. Non-invasive magnetic resonance imaging can identify intraplaque hemorrhage, a plaque characteristic that may predict future adverse cardiovascular events and progression of luminal narrowing 87 60 .…”

Section: Imaging Of the Atherosclerotic Plaque At Riskmentioning

confidence: 99%

Temporal shifts in clinical presentation and underlying mechanisms of atherosclerotic disease

2016

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The concept of "the vulnerable plaque" originated from pathological observations in patients who succumbed to fatal acute coronary syndromes. This recognition spawned a generation of research that led to achievement of considerable understanding of how complicated atherosclerotic plaques form and precipitate thrombotic events.In current practice, an increasing number of patients present with non ST-elevation myocardial infarction (NSTEMI) rather than myocardial infarction (MI) with ST-elevation Key points• An increasing number of patients presenting with myocardial infarction (MI) are diagnosed with a non ST-elevated myocardial infarction (NSTEMI) rather than a MI with ST-elevation (STEMI) and consequently survive their first event.• The shift in the clinical presentations of the acute coronary syndromes mandates a critical reassessment of the underlying mechanisms and the concept of the 3 vulnerable plaque.• The change in clinical presentation and warrant critical re-assessment of currently applied cardiovascular risk scores, pre-clinical experiments, and the usefulness of population data and samples harvested before the application of current preventive interventions.4

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Section: Imaging Of the Atherosclerotic Plaque At Riskmentioning

confidence: 99%

Temporal shifts in clinical presentation and underlying mechanisms of atherosclerotic disease

2016

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“…24 Thermography can detect plaques with high temperature, which is related to inflammation. 25 Results of preliminary investigation in humans have been reported. 26 However, the method needs additional validation, especially regarding the influence of external parameters like intracoronary blood flow.…”

Section: Description Of the Linear Regression Model Regarding Thementioning

confidence: 99%

Characterizing Vulnerable Plaque Features With Intravascular Elastography

et al. 2003

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Background-In vivo detection of vulnerable plaques is presently limited by a lack of diagnostic tools. Intravascular ultrasound elastography is a new technique based on intravascular ultrasound and has the potential to differentiate between different plaques phenotypes. However, the predictive value of intravascular elastography to detect vulnerable plaques had not been studied. Methods and Results-Postmortem coronary arteries were investigated with intravascular elastography and subsequently processed for histology. In histology, a vulnerable plaque was defined as a plaque consisting of a thin cap (Ͻ250 m) with moderate to heavy macrophage infiltration and at least 40% of atheroma. In elastography, a vulnerable plaque was defined as a plaque with a high strain region at the surface with adjacent low strain regions. In 24 diseased coronary arteries, we studied 54 cross sections. In histology, 26 vulnerable plaques and 28 nonvulnerable plaques were found. Receiver operator characteristic analysis revealed a maximum predictive power for a strain value threshold of 1.26%. The area under the receiver operator characteristic curve was 0.85. The sensitivity was 88%, and the specificity was 89% to detect vulnerable plaques. Linear regression showed high correlation between the strain in caps and the amount of macrophages (PϽ0.006) and an inverse relation between the amount of smooth muscle cells and strain (PϽ0.0001). Plaques, which are declared vulnerable in elastography, have a thinner cap than nonvulnerable plaques (PϽ0.0001). Conclusions-Intravascular elastography has a high sensitivity and specificity to detect vulnerable plaques in vitro.

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“…It has been demonstrated using thermography, both in vitro (Casscells et al 1996) and in vivo (Stefanidis et al 1999;Verheye et al 2002), that heat is released by active inflammatory cells in atherosclerotic plaques.…”

Section: Other Non-ionising Techniquesmentioning

confidence: 99%

Carotid atherosclerotic plaque characterisation by measurement of ultrasound sound speed in vitro at high frequency, 20MHz

Brewin¹,

Srodon²,

Greenwald³

et al. 2014

Ultrasonics

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Thermal detection of cellular infiltrates in living atherosclerotic plaques: possible implications for plaque rupture and thrombosis

Cited by 336 publications

References 17 publications

Temporal shifts in clinical presentation and underlying mechanisms of atherosclerotic disease

Temporal shifts in clinical presentation and underlying mechanisms of atherosclerotic disease

Characterizing Vulnerable Plaque Features With Intravascular Elastography

Carotid atherosclerotic plaque characterisation by measurement of ultrasound sound speed in vitro at high frequency, 20MHz

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