Thermal disinfection in hemodialysis using the A0 concept as dispenser

Toapanta, Néstor; Sacaluga, Luis Gil; Ojeda, F. de la Cerda; Cotén, José Ramón Molas; Lazo, Mercedes Salgueira

doi:10.1016/j.nefroe.2019.10.006

Cited by 9 publications

(8 citation statements)

References 6 publications

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“…The temperature of 46 °C was tested because heat disinfection is currently being recommended, but its dose is not clearly defined in literature reviews 16 , 17 . When heat is combined with chemical detergents, it shows better efficacy in reducing CFU, but it is still unable to completely eliminate the biofilm 18 .…”

Section: Resultsmentioning

confidence: 99%

“…In clinical settings, the development of biofilms by B. cereus can lead to infection due to the persistence of bacteria in medical devices, thus serving as a reservoir for disease 18 , 19 . Biofilm strains of B. cereus have been reported to cause nosocomial bacteremia following catheter-related infections 17 and have the potential to cause catheter-related bloodstream infections even in immunocompetent patients 13 . Studies suggest 13 , 18 that a more detailed investigation of the B. cereus group is needed, including molecular aspects involving genes in order to clarify their distribution.…”

Section: Resultsmentioning

confidence: 99%

“…Safe dialysis requires careful temperature regulation, concentration, flow rate, and pressure, as well as adequate disinfection 17 . However, all water systems are prone to unmonitored failures, even in modern systems that use more technologically advanced equipment 16 .…”

Section: Resultsmentioning

confidence: 99%

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Detection and characterization of Bacillus cereus isolated from the dialysis fluid

Sturmer

Moreira

Cargnelutti

et al. 2022

Rev. Inst. Med. trop. S. Paulo

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In this study, B. cereus was detected in dialysis fluids within international parameters (ultrapure -maximum limit of 0.1 CFU/mL for heterotrophic bacteria count) by analyzing the pellet obtained through the centrifugation method. We also investigated the ability of the B. cereus isolate to form a biofilm at different temperatures, the production of virulence factors, and the susceptibility to commercial antimicrobial agents. This study demonstrated a high ability of B. cereus to persist in the hemodialysis system, which can be explained by its broad ability to produce a biofilm at 25 °C, its relevant production of virulence factors, such as β-hemolysin, lecithinase and cereulide, and its important resistance pattern to antimicrobial drugs. In conclusion, these new findings expand the understanding that this microorganism should not be neglected and new methods for tracking it should be considered.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Detection and characterization of Bacillus cereus isolated from the dialysis fluid

Sturmer

Moreira

Cargnelutti

et al. 2022

Rev. Inst. Med. trop. S. Paulo

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“…In most thermal disinfection systems without solar radiation, the effective disinfection time is inversely proportional to the temperature. 32 To achieve effective inactivation in a short period of time, the bacterial suspension in the reaction vessel must be agitated constantly 33 and a long contact time is needed in a static medium. 34 In contrast, the combination of heat and light applied via the photothermal film in this work achieved a very high inactivation effect within a short time (20 min), which may be attributed to the interfacial heat produced by the film.…”

Section: Solar-driven Photothermal Bacterial Inactivation Efficiencymentioning

confidence: 99%

Mechanisms of Escherichia coli inactivation during solar-driven photothermal disinfection

Hong

Shi

Wang

et al. 2022

Environ. Sci.: Nano

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“…The novelty of this type of osmosis plant is represented by an optimized use of heat for disinfection based on maintaining a constant temperature over a given period to guarantee a fungicidal, bactericidal and virucidal action. The latter is achieved through calculation and measurement of the A 0 parameter, thus determining the capacity of the heat disinfection cycle, promoting the inactivation of micro-organisms [33][34][35].…”

Section: Double-osmosismentioning

confidence: 99%

The production of on-line dialysis water for extracorporeal dialysis: proposals for an increased safety upgrade: a viewpoint

Bolasco

2019

J Nephrol

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Introduction At the start of the 2000s, the progressive diffusion of high-flux extracorporeal dialysis and membranes saw an increased use of high infusion volumes injected into the patient’s blood circuit following the advent of on-line water production plants. Methodology Our 15-year experience with on-line extracorporeal methodologies using very high infusion volumes has led to the detection of errors and weaknesses, thus allowing us to correct and provide for the implementation of appropriate technology in dialysis water production plants with the aim of ensuring a higher chemical-physical, bacteriological and endotoxin quality. The initial procedures had already been outlined in the 2005 Italian Guidelines, although still today Health Technicians and Nephrologists operating in the field are unable to take on board specific integrations for on-line methods due to a lack of upgrading of documentation in both European and non-European Guidelines. Results After more than 17 years’ experience, and in view of the technological implementations developed since 2005, we wish to put forward a series of suggestions in an attempt to improve the safety of on-line water, with uses ranging from drinking water, pre-treatment, osmosis, distribution circuit, hemodialysis monitors up to the most recent update of microbiological cultures. Discussion Additional, more stringent measures are required to prevent the occurrence of acute accidents during dialysis sessions and to reduce chronic inflammation-oxidation deriving from the use of not totally ultra-pure/sterile dialysis fluids. Conclusion Our point of view based on our long-standing experience, the proposals made relate to procedures to be applied in technological maintenance, which the consultant nephrologist and other relevant personnel such as microbiologists, biologists, and technical operators should adhere to rigorously to ensure that the production of dialysis water on-line is viewed on a par with a pharmacological administration.

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Thermal disinfection in hemodialysis using the A0 concept as dispenser

Cited by 9 publications

References 6 publications

Detection and characterization of Bacillus cereus isolated from the dialysis fluid

Detection and characterization of Bacillus cereus isolated from the dialysis fluid

Mechanisms of Escherichia coli inactivation during solar-driven photothermal disinfection

The production of on-line dialysis water for extracorporeal dialysis: proposals for an increased safety upgrade: a viewpoint

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