Thermal effect of endoscopic thermal vapour ablation on the lung surface in human ex vivo tissue

Henne, Erik; Anderson, Joseph C.; Barry, Robert; Kesten, Steven

doi:10.3109/02656736.2012.677932

Cited by 4 publications

(3 citation statements)

References 24 publications

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“…During each vapor delivery, the lung surface was monitored with an infrared camera 13. The location of maximum temperature change was marked with a numbered pin to label the ablation and guide dissection.…”

Section: Methodsmentioning

confidence: 99%

Bronchoscopically Delivered Thermal Vapor Ablation of Human Lung Lesions

Ferguson

Henne²

2019

Journal of Bronchology &Amp; Interventional Pulmonology

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We conclude that BTVA may have a future role in the treatment of lung cancer and should be investigated further in clinical trials.This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc-nd/4.0/.

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Section: Methodsmentioning

confidence: 99%

Bronchoscopically Delivered Thermal Vapor Ablation of Human Lung Lesions

Ferguson

Henne²

2019

Journal of Bronchology &Amp; Interventional Pulmonology

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“…Some of these include lung volume reduction for emphysema [22], endometrial ablation, uterine fibroids [23], and varicose vein reduction. Some of these include lung volume reduction for emphysema [22], endometrial ablation, uterine fibroids [23], and varicose vein reduction.…”

Section: Vapormentioning

confidence: 99%

Emerging needle ablation technology in urology

Leveillee¹,

Pease

Salas³

2014

Current Opinion in Urology

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Needle and probe-based ablative treatments will continue to play an important role. As three-dimensional imaging workstations move from the advanced radiologic interventional suite to the operating room, surgeons will likely still play a pivotal role in the +-application of these probe ablative devices. It is essential that the surgeon understands the fundamentals of these devices in order to optimize their application.

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“…However, smaller subsegments were targeted with the intent of delivering a higher energy density to completely perfuse the parenchyma airspace with vapor (which is not the intent of the emphysema approach) [18] . Because the intent was to completely perfuse subsegments of a similar size, fixed energy levels rather than mass scaled energy doses were evaluated.…”

Section: Treatment Proceduresmentioning

confidence: 99%

Thermal Vapor Ablation for Lung Lesions in a Porcine Model

Henne¹,

Ferguson

Mest³

et al. 2015

Respiration

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Background: Various methods for ablating peripheral lung lesions are being investigated; however, none have been successfully adapted for delivery via bronchoscopy. Vapor ablation is currently being used to bronchoscopically create lung volume reduction in emphysema patients. Objectives: In this study, an adaptation of that technology is evaluated for potential treatment of lung lesions in a live pig model. Methods: In 5 anesthetized healthy pigs, vapor of varying energy levels was delivered bronchoscopically to 66 different lung subsegments with airway diameters of 2-5 mm. Two hours after treatment, a necropsy was performed and the ablated regions were assessed for ablation and tissue structure disruption. In 6 additional pigs, vapor was applied to 3 subsegments each. To evaluate the progression of the response to treatment, 2 were kept alive for 10 days, 2 for 21 days, and 2 for 32 days. Results: Histopathological evaluation of the sections demonstrated that vapor is capable of creating a uniform field of necrosis following the subsegment anatomical boundary. The reliability of a uniform field is dependent on the level of energy delivered. An energy level that reliably creates a uniform field of necrosis was applied in chronic animals. The animals tolerated the procedure and posttreatment care. No cardiac arrhythmias, hemorrhage, stroke, respiratory distress, or pneumothorax occurred during or after treatment. Conclusions: Vapor ablation is a potentially safe and efficient means of ablating a targeted region of the lung. We hypothesize that vapor may be useful in treating lesions of the lung in humans.

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Thermal effect of endoscopic thermal vapour ablation on the lung surface in human ex vivo tissue

Cited by 4 publications

References 24 publications

Bronchoscopically Delivered Thermal Vapor Ablation of Human Lung Lesions

Bronchoscopically Delivered Thermal Vapor Ablation of Human Lung Lesions

Emerging needle ablation technology in urology

Thermal Vapor Ablation for Lung Lesions in a Porcine Model

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