Thermal Environment and Acid-Base Homeostasis in Human Infants during the First Few Hours of Life*

Gandy, Gillian; Adamsons, Karlis; Cunningham, Nicholas; Silverman, William A.; James, L. Stanley

doi:10.1172/jci104959

Cited by 192 publications

(57 citation statements)

References 13 publications

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“…[1][2][3][4][5][6][7][8][9][10] The immature infant is at high risk of net heat loss because of a high surface area to volume ratio and increased evaporative fluid losses from the skin. 11 Strategies introduced to minimize heat loss include occlusive wrapping, exothermic warming mattresses, warmed humidified resuscitation gases, polyethylene caps, and higher delivery room (DR) temperatures.…”

Section: Discussionmentioning

confidence: 99%

“…[1][2][3][4][5][6][7][8][9][10] Specifically, Laptook et al 3 showed that for every degree decrease in temperature below 36.5°C, mortality increased by 28%. Regarding morbidity, observational studies have reported an association between hypothermia at birth and surfactant unresponsiveness in infants with RDS, subsequent intraventricular hemorrhage, and lateonset sepsis.…”

Section: Discussionmentioning

confidence: 99%

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Reducing Hypothermia in Preterm Infants Following Delivery

et al. 2014

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BACKGROUND: Moderate hypothermia (temperature ,36°C) at birth is common in premature infants and is associated with increased mortality and morbidity.METHODS: A multidisciplinary practice plan was implemented to determine in premature infants ,35 weeks old whether a multifaceted approach would reduce the number of inborn infants with an admitting axillary temperature ,36°C by 20% without increasing exposure to a temperature .37.5°C. The plan included use of occlusive wrap a transwarmer mattress and cap for all infants and maintaining an operating room temperature between 21°C and 23°C. Data were obtained at baseline (n = 66), during phasing in (n = 102), and at full implementation (n = 193).RESULTS: Infant axillary temperature in the delivery room (DR) increased from 36.1°C 6 0.6°C to 36.2°C 6 0.6°C to 36.6°C 6 0.6°C (P , .001), and admitting temperature increased from 36.0°C 6 0.8°C to 36.3°C 6 0.6°C to 36.7°C 6 0.5°C at baseline, phasing in, and full implementation, respectively (P , .001). The number of infants with temperature ,36°C decreased from 55% to 6.2% at baseline versus full implementation (P , .001), and intubation at 24 hours decreased from 39% to 17.6% (P = .005). There was no increase in the number of infants with a temperature .37.5°C over time. The use of occlusive wrap, mattress, and cap increased from 33% to 88% at baseline versus full implementation. Control charts showed significant improvement in DR ambient temperature at baseline versus full implementation. CONCLUSIONS:The practice plan was associated with a significant increase in DR and admitting axillary infant temperatures and a corresponding decrease in the number of infants with moderate hypothermia. There was an associated reduction in intubation at 24 hours. These positive findings reflect increased compliance with the practice plan. Dr Russo helped develop the practice plan and the algorithms, helped collect and oversee the data, and was involved in writing the manuscript; Ms McCready and Ms Venturini helped develop the practice plan and the algorithms and were involved in writing the manuscript; Ms Torres helped develop the practice plan and the algorithms, facilitated temperature regulation of the operating room and implementation of the practice plan in labor and delivery, and was involved in writing the manuscript; Ms Theuriere helped develop the practice plan and the algorithms and in review of the data and was involved in writing the manuscript; Dr Spaight helped in the data collection and was involved in writing the manuscript; Ms Hemway helped develop the practice plan and collect data and was involved in writing the manuscript; Ms Handrinos helped develop the practice plan; Ms Perlmutter and Drs Huynh and Grunebaum helped develop the practice plan and were involved in writing the manuscript; Dr Perlman was involved in developing and implementing the practice plan, conceptualized and designed the study, contributed to design of the analyses and interpretation of the results, and took the lead in drafting the init...

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Reducing Hypothermia in Preterm Infants Following Delivery

et al. 2014

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show abstract

“…In one study, newborn babies were either kept warm or left uncovered in a 22.5°C room to study prolongation of respiratory and metabolic acidosis (46). Few parents would likely enroll their infant in such a study today.…”

Section: Figure 10mentioning

confidence: 99%

Reflecting on 80 years of excellence

Savla¹

2004

J. Clin. Invest.

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“…26,27 Hyperthermia should be avoided, however, because it is associated with perinatal respiratory depression 28,29 (Class III, level of evidence [LOE] 3). Whenever possible, deliver the infant in a warm, draft-free area.…”

Section: Basic Stepsmentioning

confidence: 99%

Part 11: Neonatal Resuscitation

2000

Circulation

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Thermal Environment and Acid-Base Homeostasis in Human Infants during the First Few Hours of Life*

Cited by 192 publications

References 13 publications

Reducing Hypothermia in Preterm Infants Following Delivery

Reducing Hypothermia in Preterm Infants Following Delivery

Reflecting on 80 years of excellence

Part 11: Neonatal Resuscitation

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