Mixing ventilation systems effectively improves thermal comfort in open-spaces due to adequate turbulent mixing of the cold stream with ambient air. This study introduces the concept of precision ventilation for achieving local thermal comfort in a mixing ventilation system. This precision ventilation system provides asymmetrical airflows from an active chilled beam (ACB) to each of the office occupants. These ACBs provide air velocities with different magnitudes and directions. To achieve different magnitudes and directions, JetCones are used to vary the airflow in different parts of the ACB. The performance of the precision ventilation system was analyzed using full-scale laboratory experiments and computational fluid dynamic (CFD) simulations. The full-scale laboratory experiments were conducted in a 4.2 m × 3 m × 2.8 m (L × W × H) thermal isolated room with an open-plan dual desk-chair setup. The jet-cones in the ACB unit were adjusted to throw the required amount of flow to the occupants. The occupants had different metabolic rates of 1.2, 1.4, and 1.6 in a warm office space. The room set point temperatures varied between 23 and 26 °C. The experimental and CFD results show that occupants facing symmetrical airflow distribution and with a constant 1.2 metabolic rate had a similar PMV index. The occupants with 1.2, 1.4, and 1.6 metabolic rate were exposed to asymmetrical airflows, i.e., 30%, 58%, and 70% of the total airflow. Occupants with higher metabolic rates were kept thermally neutral, in the −0.5 to +0.5 PMV range, by increasing the air velocity and room temperature to 0.4 m/s and 25 °C, respectively.