Thermal field formation during wIRA-hyperthermia: temperature measurements in skin and subcutis of piglets as a basis for thermotherapy of superficial tumors and local skin infections caused by thermosensitive microbial pathogens

Piazena, Helmut; Müller, W.; Pendl, Wolfgang; Ah, Sereina von; Veronika, H; Hug, P; Sidler, Xaver; Pluschke, Gerd; Vaupel, Peter

doi:10.1080/02656736.2019.1655594

Cited by 11 publications

(15 citation statements)

References 35 publications

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“…wIRA could be a suitable device for achieving a homogeneous irradiation of larger skin areas, as shown recently in a study performed in piglets [31], while, e.g., heat packs lead to focal hyperthermia or even skin burns without reaching therapyrelevant temperature increases in larger skin areas or deeper skin layers. Piazena et al [31] allocated 11 piglets into three intervention groups and irradiated the skin of their thighs with different doses (irradiances) of wIRA. Skin temperatures were measured before, during and after the wIRA irradiation in a 1-min interval in tissue depths of 2,4,7,8,10,12,16, and 20 mm.…”

Section: Wira and Hyperthermiamentioning

confidence: 92%

“…Local hyperthermia facilitates the reduction of the radiation dose in the radiation therapy of cancer, which allows, e.g., re-irradiations of recurrent breast cancer [30]. wIRA could be a suitable device for achieving a homogeneous irradiation of larger skin areas, as shown recently in a study performed in piglets [31], while, e.g., heat packs lead to focal hyperthermia or even skin burns without reaching therapyrelevant temperature increases in larger skin areas or deeper skin layers. Piazena et al [31] allocated 11 piglets into three intervention groups and irradiated the skin of their thighs with different doses (irradiances) of wIRA.…”

Section: Wira and Hyperthermiamentioning

confidence: 94%

“…Skin temperatures were measured before, during and after the wIRA irradiation in a 1-min interval in tissue depths of 2,4,7,8,10,12,16, and 20 mm. The temperature measurement revealed (1) significant individual differences between temperature profiles and the thermoregulatory processes, (2) reproducible vertical temperature profiles through the skin layers and subcutis, showing the highest temperature in 4-6 mm depth of the tissue and (3) that the temperature measured at the skin surface is approximately 1-2 K lower than at 4 mm skin depth, allowing an approximate estimation of the temperature reached in deeper layers by temperature measurements at the skin surface [31].…”

Section: Wira and Hyperthermiamentioning

confidence: 96%

“…Further studies will be needed to assess the optimal time and dose exposure in thermal therapies, since the mean decay time (time after irradiation until the tissue reaches the target temperature (e.g., 39 C) has been shown to be dependent on irradiation dose, depth of tissue, and individual factors [31]. These are important parameters to consider for future wIRA use in human patients, e.g., when skin treatment of Buruli ulcer-affected patients is envisaged.…”

Section: Wira and Hyperthermiamentioning

confidence: 99%

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wIRA: hyperthermia as a treatment option for intracellular bacteria, with special focus on Chlamydiae and Mycobacteria

Borel

Sauer-Durand

Hartel

et al. 2020

International Journal of Hyperthermia

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The emergence of antibiotic-resistant bacteria in the last century is alarming and calls for alternative, nonchemical treatment strategies. Thermal medicine uses heat for the treatment of infectious diseases but its use in facultative and obligate intracellular bacteria remains poorly studied. In this review, we summarize previous research on reducing the infectious burden of Mycobacterium ulcerans and Chlamydia trachomatis by using water-filtered infrared A-radiation (wIRA), a special form of heat radiation with high tissue penetration and low thermal load on the skin surface. Mycobacterium ulcerans is a thermosensitive bacterium causing chronic necrotizing skin disease. Therefore, previous data on wIRA-induced improvement of wound healing and reduction of wound infections is summarized first. Then, pathogenesis and treatment of infections with M. ulcerans causing Buruli ulcer and of those with C. trachomatis infecting the ocular conjunctiva and resulting in blinding trachoma are discussed. Both bacteria cause neglected tropical diseases and have similar geographical distributions. Results of previous in vitro and in vivo studies using wIRA on M. ulcerans and C. trachomatis infections are presented. Finally, technical aspects of using wIRA in patients are critically reviewed and open questions driving future research are highlighted. In conclusion, wIRA is a promising tool for reducing infectious burden due to intracellular bacteria such as M. ulcerans and C. trachomatis.

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Section: Wira and Hyperthermiamentioning

confidence: 92%

Section: Wira and Hyperthermiamentioning

confidence: 94%

Section: Wira and Hyperthermiamentioning

confidence: 96%

Section: Wira and Hyperthermiamentioning

confidence: 99%

See 2 more Smart Citations

wIRA: hyperthermia as a treatment option for intracellular bacteria, with special focus on Chlamydiae and Mycobacteria

Borel

Sauer-Durand

Hartel

et al. 2020

International Journal of Hyperthermia

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“…For this purpose, data sets of invasive in vivo measurements of the thermal field formation in skin and subcutis of piglets during wIRA-irradiation were used [19].…”

Section: Introductionmentioning

confidence: 99%

wIRA-heating of piglet skin and subcutis in vivo: proof of accordance with ESHO criteria for superficial hyperthermia

Piazena

Müller²,

Vaupel

2020

International Journal of Hyperthermia

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Purpose: The quality assurance guidelines of the European Society for Hyperthermic Oncology (ESHO) specify the requirements for appropriate superficial heating using phantoms. In this current piglet study, we have examined these requirements under in vivo conditions. Materials and Methods: The evaluation is based on simultaneous, invasive temperature measurements at 8 different depths between 2 and 20 mm in the thigh of anesthetized piglets during irradiation with water-filtered infrared radiation (wIRA). Temperature probes were equally distributed in an area of 10 cm diameter of homogeneously irradiated skin. Piglets were irradiated to 126.5 mW cm À2 in the spectral range of IR-A. Results: Heating rates and specific absorption rates were in full accordance with the ESHO standards. Due to early onset of thermoregulation, the desired temperature rise of 6 K at a depth of 5 mm was achieved after about 10 min of exposure, i.e. 4 min later than required for phantoms. After reaching thermal steady state, on average T 90 ! 40 C occurred in tissue depths up to 20 mm, T 50 ! 41 C up to 16 mm, and a mean CEM 43 T 90 % 1 min was calculated for depths up to 8 mm. Conclusions: Piglet data are comparable with preliminary literature data assessed in vivo in the abdominal wall and in recurrent breast cancer of humans. The potential of wIRA-HT for adequate treatment of superficial tissues/cancers in the clinical setting thus is confirmed. To ensure therapeutically needed doses of wIRA-HT, irradiation times should be extended.

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Thermography and Thermometry in wIRA-Hyperthermia

Müller¹,

Piazena

Thomsen

et al. 2022

Water-Filtered Infrared a (wIRA) Irradiation

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Contact-free temperature determination is based on the measurements of electromagnetic radiation. The corresponding physical laws are related to the properties of black bodies. This background allows for the development of thermometric and thermographic systems for remote temperature measurements. Precise absolute temperature data, required in hyperthermia, do not only depend on the technical quality of the systems (hardware and software) and their calibration, but also depend on accurate determination of the emissivity of human skin. Pyrometers are restricted to temperature measurements within a small area (measurement spot), while thermographic cameras allow measurements across a relatively large region on the target area in real time. The subdivision of the IR image into spatially separated pixels allows access to temperature data of small areas on the skin and thus combines thermometry and thermography. Quality assurance standards of the European Society of Hyperthermic Oncology for water-filtered IR-A-hyperthermia (wIRA-HT) are met, except for the accuracy of the absolute temperature. Since the relation between the temperatures at the skin surface and in deeper tissue layers, considering irradiation and heating time, in wIRA-HT can be assessed, the temperature needed for efficient thermal treatment of superficial tumors within superficial tissue layers can therefore be achieved in a controlled manner.

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Thermal field formation during wIRA-hyperthermia: temperature measurements in skin and subcutis of piglets as a basis for thermotherapy of superficial tumors and local skin infections caused by thermosensitive microbial pathogens

Abstract: Vaupel (2019) Thermal field formation during wIRA-hyperthermia: temperature measurements in skin and subcutis of piglets as a basis for thermotherapy of superficial tumors and local skin infections caused by thermosensitive microbial pathogens,

Cited by 11 publications

References 35 publications

wIRA: hyperthermia as a treatment option for intracellular bacteria, with special focus on Chlamydiae and Mycobacteria

wIRA: hyperthermia as a treatment option for intracellular bacteria, with special focus on Chlamydiae and Mycobacteria

wIRA-heating of piglet skin and subcutis in vivo: proof of accordance with ESHO criteria for superficial hyperthermia

Thermography and Thermometry in wIRA-Hyperthermia

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