This paper develops a multi-physics interface code MC-FLUENT to couple the Monte Carlo code OpenMC with the commercial computational fluid dynamics code ANSYS FLUENT. The implementations and parallel performances of block Gauss–Seidel-type and block Jacobi-type Picard iterative algorithms have been investigated. In addition, this paper introduces two adaptive load-balancing algorithms into the neutronics and thermal-hydraulics coupled simulation to reduce the time cost of computation. Considering that the different scalability of OpenMC and FLUENT limits the performance of block Gauss–Seidel algorithm, an adaptive load-balancing algorithm that can increase the number of nodes dynamically is proposed to improve its efficiency. Moreover, with the natural parallelism of block Jacobi algorithm, another adaptive load-balancing algorithm is proposed to improve its performance. A 3 x 3 PWR fuel pin model and a 1000 MWt ABR metallic benchmark core were used to compare the performances of the two algorithms and verify the effectiveness of the two adaptive load-balancing algorithms. The results show that the adaptive load-balancing algorithms proposed in this paper can greatly improve the computing efficiency of block Jacobi algorithm and improve the performance of block Gauss–Seidel algorithm when the number of nodes is large. In addition, the adaptive load-balancing algorithms are especially effective when a case demands different computational power of OpenMC and FLUENT.