Thermal investigations of Ti and Ag-doped bioactive glasses

Wers, Éric; Oudadesse, Hassane; Lefeuvre, Bertrand; Bureau, Bruno; Merdrignac‐Conanec, Odile

doi:10.1016/j.tca.2014.02.001

Cited by 23 publications

(10 citation statements)

References 26 publications

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“…However, it can be seen that the cell viability decreases with copper oxide content in the samples. The pH behaviour is a relevant variable as the cells are highly sensitive to changes in the physiological media (pH = 7.4; Bejarano, Caviedes, & Palza, ; Wers, Oudadesse, Lefeuvre, Bureau, & Merdrignac‐Conanec, ). Evaluating the pH changes after 24 hr by immersing the composites in SBF solution, it was found that the solution pH increased from 7.4 to 7.5 and 7.6 for Alg‐Pll‐0.5CuBG and Alg‐Pll‐1.5CuBG, respectively.…”

Section: Resultssupporting

confidence: 89%

New alginate-pullulan-bioactive glass composites with copper oxide for bone tissue regeneration trials

Popescu

Magyari

Taulescu

et al. 2018

J Tissue Eng Regen Med

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Composites based on sodium alginate, pullulan, and bioactive SiO -CaO-P O glass-ceramics with copper oxide were prepared as capsules. The obtained samples were structurally characterized by Fourier transform infrared (FT-IR) spectroscopy, X-ray diffraction (XRD), and scanning electron microscopy (SEM), and their bioactivity and biocompatibility properties were also tested both in vitro and in vivo by XRD, FT-IR, SEM, and high-resolution transmission electron microscopy. The fibroblast and osteoblast cell viability assays have shown good proliferation rates for all investigated samples, whereas all composites exhibited a good in vivo tolerance. The recovered composites after 5 weeks' in vivo and in vitro trials evidenced clear macroscopic alterations; particularly, after soaking in simulated body fluid, they have a corn flake aspect, and after their in vivo inoculation, a globular shape is retained. Different crystalline shapes of hydroxyapatite were formed after in vitro and in vivo trials for the glass-ceramic-polymer composites, the in vitro precipitated apatite was found to be nodular, and the in vivo experiment led to needlelike crystallites formation. Histopathological results showed a good biocompatibility with no significant signs of rejection by the host tissue. These assessments performed on the composites indicate that the studied materials can be considered without any doubt suitable candidates for future bone regeneration applications.

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Section: Resultssupporting

confidence: 89%

New alginate-pullulan-bioactive glass composites with copper oxide for bone tissue regeneration trials

Popescu

Magyari

Taulescu

et al. 2018

J Tissue Eng Regen Med

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“…Zinc, titanium, copper, silver, magnesium, and strontium ions can be introduced in the amorphous matrix of a bioactive glass [88,[122][123][124][125][126]. They are used to improve different characteristics such as the mechanical properties, chemical reactivity, and biological properties.…”

Section: Zn-and Ti-doped Bioactive Glassesmentioning

confidence: 99%

“…The effect of Ti on the thermal behavior of 46S6 is presented in Figure 16 [123]. When the Ti content increases from 0.1 wt% to 10 wt%, the crystallization temperature increases from 611°C to 700°C, whereas the effect on the glass transition temperatures is less pronounced (increasing from 548°C to 576°C).…”

Section: Physical Propertiesmentioning

confidence: 99%

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Physical and biological characteristics of nanohydroxyapatite and bioactive glasses used for bone tissue engineering

Yousefi

Oudadesse

Akbarzadeh

et al. 2014

Nanotechnology Reviews

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Critical-sized bone defects have, in many cases, posed challenges to the current gold standard treatments. Bioactive glasses are reported to be able to stimulate more bone regeneration than other bioactive ceramics; however, the difficulty in producing porous scaffolds made of bioactive glasses has limited their extensive use in bone regeneration. On the other hand, calcium phosphate ceramics such as synthetic hydroxyapatite and tricalcium phosphate are widely used in the clinic, but they stimulate less bone regeneration. This paper gives an overview of the recent developments in the field of bioactive nanoparticles, with a focus on nanohydroxyapatite and bioactive glasses for bone repair and regeneration. First, a brief overview of the chemical structure and common methods used to produce synthetic nanohydroxyapatite and bioactive glasses has been presented. The main body of the paper covers the physical and biological properties of these biomaterials, as well as their composites with biodegradable polymers used in bone regeneration. A summary of existing challenges and some recommendations for future directions have been brought in the concluding section of this paper.

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“…Doping bioactive glasses with functional ions is important to modify their properties and enhance their interaction with the human body. Nevertheless, in most cases the doping ions were added separately, and their investigated effects were not compared to a parent glass (Bejarano, Detsch, Boccaccini, & Palza, 2017;Tylkowski & Brauer, 2013;Wers, Oudadesse, Lefeuvre, Bureau, & Merdrignac-Conanec, 2014). There have been a few systematic studies of combined doping with multiple elements, such as binary Sr 2+ -Li + dopants (Khan et al, 2016), but no such binary studies have been made on solgel derived bioglass.…”

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confidence: 99%

Cytotoxicity and bioactivity assessments for Cu²⁺ and La³⁺ doped high‐silica sol‐gel derived bioglasses: The complex interplay between additive ions revealed

Ben–Arfa

Palamà

Salvado

et al. 2019

J Biomedical Materials Res

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We show the influence of two functional ions (Cu2+ and La3+), incorporated into a quaternary (Si, Ca, Na, P) sol‐gel derived bioactive glass system, on its particle size, cytotoxicity, and bioactivity. By doping the parent glass with the two ions in singular or combined forms, 15 doped glasses were prepared by a rapid sol‐gel technique. The influence of the combined doping on the particle size and cell viability was successfully evaluated by the aid of signal‐to‐noise‐ratio (S/N), using Taguchi analysis. This allowed us to analyze the complex interplay of effects between these ions, and the marked differences in biocompatibility between the three cell types studied. Cu addition had a significant effect on reducing the glass particle size, while both increased density. Cell viability was significantly improved for some doping combinations, demonstrating that while combined Cu–La doping was beneficial for biocompatibility with lymphoblasts, individual high‐Cu or low‐La doping was better with fibroblasts, and either high‐Cu or low‐La doping, or certain combined Cu–La combinations, were the optimum for osteoblasts. However, the bioactivity of doped samples was generally similar to that of the parent glass, although both La, and particularly Cu, did appear to aid dissolution of ions when immersed in SBF, act as glass modifiers, and encourage HAp crystallization. The results reveal that potential synergistic benefits can be obtained by combining the effects on the mean particle size, density, cytotoxicity, and bioactivity of the glasses. The greatly improved biocompatibility of some of the doped glasses makes them promising candidates for biomedical applications.

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Thermal investigations of Ti and Ag-doped bioactive glasses

Cited by 23 publications

References 26 publications

New alginate-pullulan-bioactive glass composites with copper oxide for bone tissue regeneration trials

New alginate-pullulan-bioactive glass composites with copper oxide for bone tissue regeneration trials

Physical and biological characteristics of nanohydroxyapatite and bioactive glasses used for bone tissue engineering

Cytotoxicity and bioactivity assessments for Cu²⁺ and La³⁺ doped high‐silica sol‐gel derived bioglasses: The complex interplay between additive ions revealed

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Thermal investigations of Ti and Ag-doped bioactive glasses

Cited by 23 publications

References 26 publications

New alginate-pullulan-bioactive glass composites with copper oxide for bone tissue regeneration trials

New alginate-pullulan-bioactive glass composites with copper oxide for bone tissue regeneration trials

Physical and biological characteristics of nanohydroxyapatite and bioactive glasses used for bone tissue engineering

Cytotoxicity and bioactivity assessments for Cu2+ and La3+ doped high‐silica sol‐gel derived bioglasses: The complex interplay between additive ions revealed

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Product

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Cytotoxicity and bioactivity assessments for Cu²⁺ and La³⁺ doped high‐silica sol‐gel derived bioglasses: The complex interplay between additive ions revealed