Water cooled mini channels have gained importance because of high heat generation inside the microprocessors. This generated heat needs to be timely removed for maintaining the durability and performance of the microprocessor. This work proposes a two-pronged strategy for thermal performance enhancement of mini channel heat sinks. Firstly, a novel dual flow slotted fin mini channel heat sink flow configuration is proposed. Secondly, a detailed numerical investigation is performed to assess heat transfer enhancement property of Al2O3-H2O and TiO2-H2O nanofluids. Considering the first step, fin spacing, number of slots, slot thickness and slot angle are investigated in detail yielding to the selection of best structural parameters. Further, numerical assessment of nano fluid behavior is carried out at volumetric concentrations of 0.005% and 0.01%. For the case of novel dual flow slotted fin mini channel heat sink, maximum numerical and experimental reduction in base temperature and thermal resistance is observed for Al2¬O3-H2O nano fluid at volumetric concentration of 0.01%, as compared with water. Increment in the pressure drop is noted with increasing volumetric concentrations.