Hybrid nanofluids have many real-world applications. Research has shown that mixed nanofluids facilitate heat transfer better than nanofluids with one type of nanoparticle. New applications for this type of material include microfluidics, dynamic sealing, and heat dissipation. In this study, we began by placing copper into H2O to prepare a Cu-H2O nanofluid. Next, Cu-H2O was combined with Al2O3 to create a Cu-Al2O3-H2O hybrid nanofluid. In this article, we present an analytical study of the estimated flows and heat transfer of incompressible three-dimensional magnetohydrodynamic hybrid nanofluids in the boundary layer. The application of similarity transformations converts the interconnected governing partial differential equations of the problem into a set of ordinary differential equations. Utilizing the homotopy analysis method (HAM), a uniformly effective series solution was obtained for the entire spatial region of 0 < η < ∞. The errors in the HAM calculation are smaller than 1 × 10−9 when compared to the results from the references. The volume fractions of the hybrid nanofluid and magnetic fields have significant impacts on the velocity and temperature profiles. The appearance of magnetic fields can alter the properties of hybrid nanofluids, thereby altering the local reduced friction coefficient and Nusselt numbers. As the volume fractions of nanoparticles increase, the effective viscosity of the hybrid nanofluid typically increases, resulting in an increase in the local skin friction coefficient. The increased interaction between the nanoparticles in the hybrid nanofluid leads to a decrease in the Nusselt number distribution.