This paper investigated the dynamic coupling heat transfer characteristics of rock and air in a Mine Refuge Chamber (MRC) under ventilation. In the current work, a comprehensive fiftyperson MRC model combining human-body heat sources and ventilation is established, the proposed model is validated against available experimental data with deviation less than 4%. Furthermore, sensitivity analysis is performed to investigate the influence of several control parameters such as heating rate, ventilation and wall area in a MRC through using numerical simulation. Results indicated that: (ⅰ) the heat transfer process in a MRC will reach a stage of air temperature slow increase (ATSI) in less than 0.5 h. The air temperature rises linearly with the square root of time during the ATSI stage; (ⅱ) for a MRC built in a sandstone seam with an initial rock temperature of less than 27 °C, the average air temperature will not exceed 35 °C in 96 h when the ventilation volume rate is 0.3 m 3 /min per person; (ⅲ) the rate of temperature rise in MRC is proportional to the rate of heat generation, but it is inversely proportional to the thermal conductivity, density and thermal capacity of the rock, as well as the ventilation volume rate and the wall area; (ⅳ) an empirical correlation for the MRC average air temperature is developed while the supply air temperature equals to the initial rock temperature. Keywords:Underground; Mine refuge chamber; Air temperature prediction; Ventilation; Heat transfer coefficient; Human body heat sources. Nomenclature a Constant in K expression V Ventilation volume for MRC, m 3 /h A w Wall area of MRC, m 2 x, y Coordinate direction vector b Constant in K expression Subscripts B Temperature variable, °C a Air c Constant in K expression num Numerical data C a Specific heat capacity of air, J/(kg• K) exp Experimental data C p Specific heat capacity of rock, J/(kg• K) Greek symbols d Constant in K expression α Surface heat transfer coefficient, W/(m 2 • K) i, j Constant in B expression Θ Difference k Constant in B expression ρ Density of rock, kg/m 3 K Rate for air temperature increasing, °C/s 0.5 ρ a Density of air, kg/m 3 l Constant in B expression λ Thermal conductivity of rock, W/(m• K) L Temperature variable, °C τ Heat time, h L c Perimeter of cross-section tunnel, m Acronyms m, n Constant in K expression ATSI Air temperature slow increase p Pressure, Pa CE Critical equilibrium Q Total heat generation rate in MRC, W MRC Mine refuge chamber r 0 equivalent radius of cross-section tunnel, m MMRC Movable mine rescue capsules T Temperature, °C PCM Phase change materials T 0 Initial rock temperature, °C