Investigating thermal breakage of glass panes requires careful analysis of the environmental boundary conditions to determine the expected thermal gradient between the sunlit and shaded parts of the glass. This is particularly critical for glazed spandrels, where an opaque posterior insulation layer normally increases the system’s temperatures. The choice of the spandrel system should also be evaluated against the aesthetical impression that it conveys. The aim of this study is to understand how early design factors, such as aesthetical features like color, are driving temperature gradients in the glazed pane to design for thermal shock. Multiple finite-differences analyses in a quasi-static regime for non-ventilated, single glazed spandrels were conducted in three locations (London, New York and Mumbai). Results were then analyzed via a general linear model in SAS 9.4 and Tuckey post hoc analysis. It was shown that a low absorptance of the back insulation (e.g., light color) can lead to a wide range of possible temperature gradients depending on the glass transparency, with higher values of the thermally induced temperature gradients for more opaque glasses. Conversely, a high absorptance of the insulation layer leads to moderate values of glass temperature gradients, which are not substantially sensitive to the effect of the glass transparency.