In this paper, for a highly coupled two-stage ejector-based cooling cycle, the optimization of primary nozzle length and angle of the second-stage ejector under varied primary nozzle diameters of the second stage was conducted first. Next, the evaluation for the influence of variable back pressure on ER of the two-stage ejector was performed. Last, the identification of the effect of the variable back pressure on the key geometries of the two-stage ejector was carried out. The results revealed that: (1) with the increase of the nozzle diameter at the second stage, the ER of both stages decreased with the increases of the length and angle of the converging section of the second-stage primary nozzle; (2) the pressure lift ratio range of the second-stage ejector in the critical mode gradually increased with the increase of the nozzle diameter of the second-stage; (3) when the pressure lift ratio increased from 102% to 106%, the peak ER of the second-stage decreased, and the influence of the area ratio and nozzle exit position of the second-stage ejector on its ER was reduced; (4) with the increase of nozzle diameter of the second-stage, the influence of area ratio and nozzle exit position of the second-stage on the second-stage performance decreased; and (5) the optimal AR of the second stage decreased but the optimal nozzle exit position of the second stage kept constant with the pressure lift ratio of the two-stage ejector.