The predicted mean vote (PMV) and predicted percentage of dissatisfied (PPD) are the most widely used thermal comfort indices. Yet, their performance remains a contested topic. The ASHRAE Global Thermal Comfort Database II, the largest of its kind, was used to evaluate the prediction accuracy of the PMV/PPD model. We focused on: (i) the accuracy of PMV in predicting both observed thermal sensation (OTS) or observed mean vote (OMV) and (ii) comparing the PMV-PPD relationship with binned OTS -observed percentage of unacceptability (OPU). The accuracy of PMV in predicting OTS was only 34%, meaning that the thermal sensation is incorrectly predicted two out of three times. PMV had a mean absolute error of one unit on the thermal sensation scale and its accuracy decreased towards the ends of the thermal sensation scale. The accuracy of PMV was similarly low for air-conditioned, naturally ventilated and mixed-mode buildings. In addition, the PPD was not able to predict the dissatisfaction rate. If the PMV model would perfectly predict thermal sensation, then PPD accuracy is higher close to neutrality but it would overestimate dissatisfaction by approximately 15-25% outside of it. Furthermore, PMV-PPD accuracy varied strongly between ventilation strategies, building types and climate groups. These findings demonstrate the low prediction accuracy of the PMV-PPD model, indicating the need to develop high prediction accuracy thermal comfort models. For demonstration, we developed a simple thermal prediction model just based on air temperature and its accuracy, for this database, was higher than PMV.