Thermal Plasma Spraying as a New Approach for Preparation of Zinc Biodegradable Scaffolds: A Complex Material Characterization

Čapek, Jaroslav; Pinc, Jan; Msallamová, Šárka; Jablonská, Eva; Veřtát, Petr; Kubásek, Jiří; Vojtěch, Dalibor

doi:10.1007/s11666-019-00849-1

Cited by 16 publications

(9 citation statements)

References 45 publications

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“…Details of the procedure are given in 14 . Zn_SPS sample was prepared by cold pressing of pure Zn powder into a green compact and subsequent spark plasma sintering at 300 °C with details of the processing in 15 . Zn-0.8 Mg was prepared by the general casting process and subsequent extrusion at 300 °C at a rate of 5 mm/min and extrusion ratio equal to 10, which is in more details described in 16 .…”

Section: Methodsmentioning

confidence: 99%

Test conditions can significantly affect the results of in vitro cytotoxicity testing of degradable metallic biomaterials

Jablonská

Kubásek

Vojtěch

et al. 2021

Sci Rep

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In vitro cytotoxicity testing is an indispensable part of the development of new biomaterials. However, the standard ISO 10993-5 enables variability in the testing conditions, which makes the results of the test incomparable. We studied the influence of media composition on the results of the cytotoxicity test. Solutions of ZnCl2 served as simulated extracts and we also used extracts of three types of Zn-based and Mg-based degradable metals. We incubated the cells with the solutions prepared in two types of media with two concentrations of serum (5 and 10%). We compared the toxic effect of the extracts on L929 murine fibroblast-derived cell line, which is recommended by ISO standard and on “osteoblast-like cells” U-2 OS. We also compared two methods of exposition: solutions were added either to a sub-confluent layer or to the cell suspension. We evaluated the metabolic activity of the cells using the resazurin test. We found out that in vitro cytotoxicity is dramatically influenced by the concentration of serum and by the type of the medium as well as by the type of exposition and type of cells. Therefore, when performing in vitro cytotoxicity testing of biomaterials, the authors should carefully specify the conditions of the test and comparison of different studies should be carried out with caution.

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Section: Methodsmentioning

confidence: 99%

Test conditions can significantly affect the results of in vitro cytotoxicity testing of degradable metallic biomaterials

Jablonská

Kubásek

Vojtěch

et al. 2021

Sci Rep

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“…One of the structural key factors of the biomaterials is porosity. Porosity inhibits the stress shield effect due to the decrease in the Young modulus compared to bulk materials, which have a higher Young modulus than human bones [6,7]. Porosity also affects the corrosion process through surface area changes [8].…”

Section: Introductionmentioning

confidence: 99%

Characterization of a Zn-Ca5(PO4)3(OH) Composite with a High Content of the Hydroxyapatite Particles Prepared by the Spark Plasma Sintering Process

Pinc

Čapek

Kubásek

et al. 2020

Metals

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Zinc and zinc alloys have been studied due to their corrosion properties as potentially biodegradable materials. In this study, a zinc/hydroxyapatite composite (Zn/HA) containing 16 wt % HA was prepared by spark plasma sintering and characterized in detail. The microstructure, mechanical and corrosion properties were studied and the mutual relations between properties and microstructure were found. The porosity was evaluated to be approximately 18%. The mechanical properties (ultimate compression strength = 65 MPa and ultimate flexural strength = 120 MPa) are sufficient for the potential scaffolding and augmentation of cancellous bone. The flexural properties of these materials were measured for the first time. Immersion tests and subsequent analyses confirmed no direct participation of hydroxyapatite in the corrosion process and an ideal corrosion rate of approximately 0.4 mm/year. The amount of released zinc was between 4–6 mg/day corresponding with the maximal usable surface area of 25 cm2. All the results suggest that the Zn/HA composite is suitable as a potential biodegradable material (from the point of view of mechanical and corrosion properties) for the replacement of cancellous bones.

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“…Zhao et al were the first to manufacture porous Zn scaffolds for bone applications and found that the mechanical properties were not sufficient for load-bearing applications [196]. Since 2018, over half a dozen papers been published on this topic [195][196][197][198][199][200][201][202], however, none of these studies reported Zn alloys that had sufficient strength for load-bearing (cortical bone) applications (Table 1) as porosity decreases the mechanical properties of the bulk material [203].…”

Section: Zinc and Alloysmentioning

confidence: 99%

Challenges and Opportunities in the Selective Laser Melting of Biodegradable Metals for Load-Bearing Bone Scaffold Applications

Carluccio

Demir

Bermingham

et al. 2020

Metall Mater Trans A

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The aim of this paper is to assess the current status of processing Biodegradable metals (BDM) via selective laser melting (SLM), with particular emphasis on bone scaffold applications, and provide a meta-analysis on the effect of processing parameters on relative density to better direct recommendations for the future of this growing field. Synthetic bone scaffolds are becoming a popular alternative for the treatment of critical bone defects that cannot heal without surgical intervention.These scaffolds act as a bridge allowing bone to grow across the gap. Selective laser melting can achieve bone scaffolds with complex hierarchical architecture tailored specifically to the patient. SLM manufactured titanium scaffolds have already been clinically tested with some success. Permanent titanium alloys have a higher chance of implant rejection from the innate immune reaction, coupled with complications linked to the high mismatch in stiffness between the implant and the bone. Biodegradable metals can overcome these problems by maintaining sufficient mechanical properties for load-bearing applications during healing and eventually

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Thermal Plasma Spraying as a New Approach for Preparation of Zinc Biodegradable Scaffolds: A Complex Material Characterization

Cited by 16 publications

References 45 publications

Test conditions can significantly affect the results of in vitro cytotoxicity testing of degradable metallic biomaterials

Test conditions can significantly affect the results of in vitro cytotoxicity testing of degradable metallic biomaterials

Characterization of a Zn-Ca5(PO4)3(OH) Composite with a High Content of the Hydroxyapatite Particles Prepared by the Spark Plasma Sintering Process

Challenges and Opportunities in the Selective Laser Melting of Biodegradable Metals for Load-Bearing Bone Scaffold Applications

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