Thermal Properties of Human Soft Tissue and Its Equivalents in a Wide Low-Temperature Range

Agafonkina, I. V.; Belozerov, A. G.; Vasilyev, A. O.; Пушкарев, А. В.; Tsiganov, D. I.; Шакуров, А. В.; Жердев, А. А.

doi:10.1007/s10891-021-02292-y

Cited by 16 publications

(5 citation statements)

References 27 publications

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“…Considering the pancreas, the study of Valvano et al is one of the few reports about the thermal properties of this organ [ 28 ], along with a recent report on the specific heat capacity measurement in the temperature range from −160 to 40 °C, using differential scanning calorimetry [ 37 ].…”

Section: Introductionmentioning

confidence: 99%

Measurement of Ex Vivo Liver, Brain and Pancreas Thermal Properties as Function of Temperature

Mohammadi

Bianchi

Asadi

et al. 2021

Sensors

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The ability to predict heat transfer during hyperthermal and ablative techniques for cancer treatment relies on understanding the thermal properties of biological tissue. In this work, the thermal properties of ex vivo liver, pancreas and brain tissues are reported as a function of temperature. The thermal diffusivity, thermal conductivity and volumetric heat capacity of these tissues were measured in the temperature range from 22 to around 97 °C. Concerning the pancreas, a phase change occurred around 45 °C; therefore, its thermal properties were investigated only until this temperature. Results indicate that the thermal properties of the liver and brain have a non-linear relationship with temperature in the investigated range. In these tissues, the thermal properties were almost constant until 60 to 70 °C and then gradually changed until 92 °C. In particular, the thermal conductivity increased by 100% for the brain and 60% for the liver up to 92 °C, while thermal diffusivity increased by 90% and 40%, respectively. However, the heat capacity did not significantly change in this temperature range. The thermal conductivity and thermal diffusivity were dramatically increased from 92 to 97 °C, which seems to be due to water vaporization and state transition in the tissues. Moreover, the measurement uncertainty, determined at each temperature, increased after 92 °C. In the temperature range of 22 to 45 °C, the thermal properties of pancreatic tissue did not change significantly, in accordance with the results for the brain and liver. For the three tissues, the best fit curves are provided with regression analysis based on measured data to predict the tissue thermal behavior. These curves describe the temperature dependency of tissue thermal properties in a temperature range relevant for hyperthermia and ablation treatments and may help in constructing more accurate models of bioheat transfer for optimization and pre-planning of thermal procedures.

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Section: Introductionmentioning

confidence: 99%

Measurement of Ex Vivo Liver, Brain and Pancreas Thermal Properties as Function of Temperature

Mohammadi

Bianchi

Asadi

et al. 2021

Sensors

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“…The specific heat for the porcine pancreas tissue at constant volume (C v ) was reported in recent literature [52] and used in this study with the assumption that, at low temperatures (22 • C), the difference between C p and C v was negligible. To assess the sensitivity of the model to this parameter, additional simulations were conducted using the C p value reported for the human pancreas by Agafonkina et al [53]. These simulation results showed a higher deviation (>5%) when compared to the experimental results of the porcine pancreas tissue.…”

Section: Results Of Computational Modellingmentioning

confidence: 99%

Assessment and Modeling of Plasmonic Photothermal Therapy Delivered via a Fiberoptic Microneedle Device Ex Vivo

et al. 2021

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Plasmonic photothermal therapy (PPTT) has potential as a superior treatment method for pancreatic cancer, a disease with high mortality partially attributable to the currently non-selective treatment options. PPTT utilizes gold nanoparticles infused into a targeted tissue volume and exposed to a specific light wavelength to induce selective hyperthermia. The current study focuses on developing this approach within an ex vivo porcine pancreas model via an innovative fiberoptic microneedle device (FMD) for co-delivering light and gold nanoparticles. The effects of laser wavelengths (808 vs. 1064 nm), irradiances (20–50 mW·mm−2), and gold nanorod (GNR) concentrations (0.1–3 nM) on tissue temperature profiles were evaluated to assess and control hyperthermic generation. The GNRs had a peak absorbance at ~800 nm. Results showed that, at 808 nm, photon absorption and subsequent heat generation within tissue without GNRs was 65% less than 1064 nm. The combination of GNRs and 808 nm resulted in a 200% higher temperature rise than the 1064 nm under similar conditions. A computational model was developed to predict the temperature shift and was validated against experimental results with a deviation of <5%. These results show promise for both a predictive model and spatially selective, tunable treatment modality for pancreatic cancer.

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“…Brown, Melsungen, Germany). It has thermal [48,49] and optical [50][51][52] properties similar to biotissues. The phantom temperature was ambient (24 • C).…”

Section: Calibrationmentioning

confidence: 99%

Optical Sensing of Tissue Freezing Depth by Sapphire Cryo-Applicator and Steady-State Diffuse Reflectance Analysis

Zotov,

Pushkarev,

Alekseeva

et al. 2024

Sensors

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This work describes a sapphire cryo-applicator with the ability to sense tissue freezing depth during cryosurgery by illumination of tissue and analyzing diffuse optical signals in a steady-state regime. The applicator was manufactured by the crystal growth technique and has several spatially resolved internal channels for accommodating optical fibers. The method of reconstructing freezing depth proposed in this work requires one illumination and two detection channels. The analysis of the detected intensities yields the estimation of the time evolution of the effective attenuation coefficient, which is compared with the theoretically calculated values obtained for a number of combinations of tissue parameters. The experimental test of the proposed applicator and approach for freezing depth reconstruction was performed using gelatin-based tissue phantom and rat liver tissue in vivo. It revealed the ability to estimate depth up to 8 mm. The in vivo study confirmed the feasibility of the applicator to sense the freezing depth of living tissues despite the possible diversity of their optical parameters. The results justify the potential of the described design of a sapphire instrument for cryosurgery.

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Thermal Properties of Human Soft Tissue and Its Equivalents in a Wide Low-Temperature Range

Cited by 16 publications

References 27 publications

Measurement of Ex Vivo Liver, Brain and Pancreas Thermal Properties as Function of Temperature

Measurement of Ex Vivo Liver, Brain and Pancreas Thermal Properties as Function of Temperature

Assessment and Modeling of Plasmonic Photothermal Therapy Delivered via a Fiberoptic Microneedle Device Ex Vivo

Optical Sensing of Tissue Freezing Depth by Sapphire Cryo-Applicator and Steady-State Diffuse Reflectance Analysis

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