“…Pain is considered, by people with osteoarthritis, to be the most important symptom they experience (Tallon 2000). However, the causes of pain in osteoarthritis are multifactorial, complex and poorly understood (Thakur 2014). With increasing severity of radiographic osteoarthritis, the presence of pain increases, although the severity of pain is not strongly related to the structural severity of the disease (Felson 2005).…”