Thermal Pulse Decay Method for Simultaneous Measurement of Local Thermal Conductivity and Blood Perfusion: A Theoretical Analysis

Arkin, H.; Holmes, Kate; Chen, M. M.; Bottje, Walter

doi:10.1115/1.3138604

Cited by 47 publications

(11 citation statements)

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“…To show the effects of the initial power supplied to the bead, the perfusion error is plotted against the measurement time in figure 8 with initial powers of 13,15,17,19 and 100 mW. As shown in the figure, larger initial powers will produce smaller blood perfusion errors.…”

Section: Resultsmentioning

confidence: 98%

A sensitivity analysis of the step-temperature technique for measurement of local tissue blood perfusion

Yang

Liu

2008

Journal of Medical Engineering & Technology

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The step-temperature technique is a thermal technique that uses a small thermistor probe for measuring blood perfusion of tissue. The blood perfusion is derived from temperature and power measurements using equations that describe heat transfer in the integrated probe/tissue system. A numerical experiment is used to analyse the theoretical error caused by the assumptions used in the technique. The effects of the bead parameters, tissue parameters and measurement parameters are investigated. The study results are in accordance with experimental phenomena described previously. An optimal measurement time window is found to be 4-10 s, dependent mainly on the thermal conductivity and blood perfusion of tissue measured. This research will lead to reduce perfusion measurement errors.

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Section: Resultsmentioning

confidence: 98%

A sensitivity analysis of the step-temperature technique for measurement of local tissue blood perfusion

Yang

Liu

2008

Journal of Medical Engineering & Technology

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“…In the past, both contact and non-contact techniques have been explored for wound temperature monitoring [32][33][34] . Tissue perfusion was also evaluated by measuring temperature changes in response to external stimulations, such as thermal pulse and vessel occlusion [35][36][37] . The dual-mode imaging system integrates a ThermoVision A40M thermal camera (FLIR systems, MA), an ORCA-ER CCD camera (Hamamatsu, Japan), a VariSpec liquid crystal tunable filter (LCTF, VariSpec, CRI) and an OSL1 high intensity fiber light source (Thorlabs, NJ), as shown in Figure 1.The thermal camera has a spectral range of 7.5 to 13 μm, a spatial resolution of 1.3 mrad, and a thermal sensitivity of 0.08°C.…”

Section: Introductionmentioning

confidence: 99%

Dual-mode quantitative imaging of wound tissue oxygenation and perfusion

Qin

Huang

et al. 2010

SPIE Proceedings

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Accurate assessment of wound oxygenation and perfusion is important for evaluating wound healing/regression and guiding following therapeutic processes. However, many existing techniques and clinical practices are subjective and qualitative due to background bias, tissue heterogeneity, and inter-patient variation. To overcome these limitations, we developed a dual-modal imaging system for in vivo, non-invasive, real-time quantitative assessment of wound tissue oxygenation and perfusion. The imaging system integrated a broadband light source, a high-resolution CCD camera, a highly sensitive thermal camera, and a liquid crystal tunable filter. A user-friendly interface was developed to control all the components systematically. Advanced algorithms were explored for reliable reconstruction of tissue oxygenation and appropriate co-registration between thermal images and multispectral images. Dual-mode oxygenation and perfusion imaging was demonstrated on both benchtop models and human subjects, and compared with measurements using other methods, such as Laser Doppler and tissue oximeter. The test results suggested that the dual-modal imaging system has the potential for non-contact real-time imaging of wound tissue oxygenation and perfusion.

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“…Perfusion is defined as the nonvectorial volumetric blood flow per tissue volume in a region that contains sufficient capillaries that an average flow description is considered reasonable. Pennes' model was adapted by many biologists for the analysis of various heat transfer phenomena in a living body [2][3][4][5][6][7]. Others, after evaluations of the Pennes model in specifical situations, have concluded that many of the hypotheses (foundational to the model) are not valid.…”

Section: Introductionmentioning

confidence: 99%

Investigation of nonlinear temperature distribution in biological tissues by using bioheat transfer equation of Pennes’ type

Lakhssassi¹,

Kengne²,

Semmaoui³

2010

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In this paper, a two level finite difference scheme of Crank-Nicholson type is constructed and used to numerically investigate nonlinear temperature distribution in biological tissues described by bioheat transfer equation of Pennes' type. For the equation under consideration, the thermal conductivity is either depth-dependent or temperature-dependent, while blood perfusion is temperature-dependent. In both cases of depthdependent and temperature-dependent thermal conductivity, it is shown that blood perfusion decreases the temperature of the living tissue. Our numerical simulations show that neither the localization nor the magnitude of peak temperature is affected by surface temperature; however, the width of peak temperature increases with surface temperature.

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Thermal Pulse Decay Method for Simultaneous Measurement of Local Thermal Conductivity and Blood Perfusion: A Theoretical Analysis

Cited by 47 publications

References 0 publications

A sensitivity analysis of the step-temperature technique for measurement of local tissue blood perfusion

A sensitivity analysis of the step-temperature technique for measurement of local tissue blood perfusion

Dual-mode quantitative imaging of wound tissue oxygenation and perfusion

Investigation of nonlinear temperature distribution in biological tissues by using bioheat transfer equation of Pennes’ type

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