This paper explores the effects of thermal radiation, buoyancy force, chemical reaction, and activation energy on magnetohydrodynamic (MHD) nanofluid flow past a stretching vertical surface. The resulting nonlinear momentum, energy, solute, and nanoparticle concentration boundary layer equations are simplified by the transformation of similarity. The transformed equations solved numerically by using the shooting technique. For various related parameters, the corresponding results to the dimensionless velocity, temperature, solute, nanoparticle concentration profiles, Skin friction, local Nusselt number, local Sherwood number, and local nanoparticle Sherwood number are illustrated graphically. It is found that the temperature, and nanoparticle concentration profiles increase on increasing thermal radiation and temperature difference parameters. With the increase of the regular buoyancy parameters, the local Nusselt number decreases on increasing the fitting rate constant, Biot number, and thermal radiation parameters.