In this research, two different diesel oil-based nanofluids were prepared and the influence of temperature and nanoparticle content were examined on viscosity, tribological, and physicochemical features of diesel oil. The kinematic viscosity of samples was experimentally evaluated based on standard ASTM D445. The greatest viscosity increment was diagnosed at 0.7 wt.% and 100°C for both of the prepared nanofluids. The anti-friction behavior of the nanofluids was studied utilizing a pin-on-disc tribometer. The acquired outcomes revealed that ZnO and MoS 2 nanoparticles (NPs) could promote the tribological characteristics of pure diesel oil. By analyzing the friction coefficient values and line roughness of the wear surface (Ra), an optimal concentration of ZnO and MoS 2 nanoparticles (NPs) were found to be around 0.4 wt.% and 0.7 wt.%, respectively. The friction factor and pumping power were also measured at diverse content of nanoparticles and flow rates showing that the pumping power was enhanced by the incorporation of nanoparticles.