Thermal shielding performance of self-healing hydrogel in tumor thermal ablation

Survival benefit of thermal ablation therapy for patients with stage II-III non-small cell lung cancer: A propensity-matched analysis

“…Cox proportional hazard analyses were performed to distinguish between several groups that benefitted more from TA. TA improved the OS and CSS of patients who were white or C can cause cellular membrane lysis, protein denaturation, and enzyme inactivation, which lead to rapid coagulative necrosis (15,44). Second, in the tumor periphery beyond the border of immediate tissue coagulation, TA can cause indirect thermal injuries, including vascular injury, ischemia-reperfusion, release of lysosomal contents (16,45,46).…”

“…MWA devices use higher frequency electromagnetic waves than RFA, allowing larger tissue volumes to be heated ( 13 ). Thermal injuries caused by TA may result in protein denaturation, enzyme inactivation, vascular injury, and ischemia-reperfusion, leading to irreversible cellular damage ( 15 , 16 ). Previous studies indicate that TA is beneficial for stage I NSCLC patients ( 7 , 17 – 19 ).…”

Development and preclinical evaluation of multifunctional hydrogel for precise thermal protection during thermal ablation

“…To solve the clinical limitations of 5% Glu, researchers have focused on alternative biomaterials with relatively higher viscosities but comparable thermal protection [ [46] , [47] , [48] , [49] , [50] ]. Thermoprotective hydrogels have been developed for this purpose, and their feasibility as an alternative to conventional liquids has been evaluated [ 47 , 49 , 50 ].…”

“…To solve the clinical limitations of 5% Glu, researchers have focused on alternative biomaterials with relatively higher viscosities but comparable thermal protection [ [46] , [47] , [48] , [49] , [50] ]. Thermoprotective hydrogels have been developed for this purpose, and their feasibility as an alternative to conventional liquids has been evaluated [ 47 , 49 , 50 ]. For example, a thermosensitive poloxamer 407 hydrogel (F127) was studied and shown to create a more durable barrier between the tumor and surrounding organ(s) after injection of a reduced volume compared with the liquid volume injected while still protecting nontarget tissues from thermal damage during the TA procedure [ 47 , 51 , 52 ].…”

Multicomponent carrier-free nanodrugs for cancer treatment

“…The mortality and monetary burden caused by cancer is enormous. 1 Clinically, the main therapy for most cancers involves surgery, 2,3 chemotherapy 4,5 and radiotherapy. 6 However, most anticancer drugs exhibit limitations such as poor water solubility, low bioavailability, high toxicity, limited stability, and rapid blood clearance, thus causing serious obstacles to cancer treatment.…”