Thermal stress causes oxidative stress and physiological changes in female rabbits

Mutwedu, Valence Bwana; Nyongesa, Albert W.; Oduma, Jemimah A.; Kitaa, J. M. A.; Mbaria, James Mucunu

doi:10.1016/j.jtherbio.2020.102780

Cited by 22 publications

(27 citation statements)

References 36 publications

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“…Indeed, the presence of this syndrome in both pathological conditions was confirmed by the detection of characteristic laboratory shifts, including the intensification of free radical oxidation in the blood plasma, as well as suppression of its antioxidant reserves. These results confirm our previously published results [18][19][20][21][22][23][24][25] and those of other authors 19,20,23,26,27 . At the same time, the persistent nature of these disorders is emphasized by the detection of increased levels of diene conjugates which increase about equally in patients with burns and osteomyelitis.…”

Section: Discussionsupporting

confidence: 93%

“…A few studies have been recently devoted to this issue. Thus, there is evidence of the involvement of oxidative stress in the pathogenesis of thermal trauma [18][19][20][21] and chronic post-traumatic inflammatory processes, such as osteomyelitis [22][23][24] . However, there is no information about the formation and progression of oxidative stress in these diseases.…”

Section: Introductionmentioning

confidence: 99%

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Oxidative stress in osteomyelitis and burns: Specific features of its role in development of pathology

et al. 2021

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Introduction: The purpose of this study was to evaluate and compare the features of the initiation and development of oxidative stress in patients with osteomyelitis and burns. Methods: We studied the oxidative metabolism of blood of 20 healthy subjects (controls), 15 patients with burns, and 18 patients with chronic osteomyelitis. All patients included in the second group had thermal burns of the I-II-III degree in trunk and limbs on an area of 31-80% of the body surface without thermal inhalation trauma. After standard sample preparation, a wide range of parameters of oxidative metabolism was determined in the blood. The intensity of free radical processes in blood plasma and red blood cells, and the total antioxidant activity was evaluated by Fe-induced biochemiluminescence. The concentration of malonic dialdehyde in blood plasma and red blood cells was determined. The level of diene and triene conjugates and Schiff bases was determined spectrophotometrically using reagent kits. The catalase and superoxide dismutase activities in the red blood cells of patients from each of the groups was also determined. Results: We showed that in osteomyelitis, which is a long-lasting process, changes in the balance of free radical generation and activity of the antioxidant system were compensatory and mostly related to changes in blood plasma. On the contrary, in burn victims, oxidative stress signs had a maladaptive character. They were seen in blood plasma and red blood cells, and accompanied by a pronounced depletion of enzyme antioxidant system reserves. Conclusion: Our study demonstrate the role of oxidative stress in patients with burns and chronic osteomyelitis, and demonstrate some specific features leading to formation of disease pathology. Such features of oxidative stress may be useful in future design of new approaches to correct the pathology of diseases.

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Section: Discussionsupporting

confidence: 93%

Section: Introductionmentioning

confidence: 99%

Oxidative stress in osteomyelitis and burns: Specific features of its role in development of pathology

et al. 2021

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“…Under heat stress, female rabbits express a high respiratory rate and water intake and low feed intake as adaptive mechanisms for high ambient temperature, which may negatively affect rabbit does’ reproductive performance if maintained for a long time [ 32 , 33 ]. For example, exposure of New Zealand rabbits to 41 °C led to an 18% decrease in RBC count; 20%, hemoglobin content; 22%, blood platelet count; 11.2%, total protein; 24%, albumin, and 21%, globulin [ 4 ]. Under intensive production systems, as in most rabbit farms, these biological and behavioral responses could be more challenging when animals are housed in cages rather than in natural environments [ 34 ].…”

Section: Discussionmentioning

confidence: 99%

“…Furthermore, heat stress may be a threat to females, specifically during sensitive reproductive windows, such as mating and pregnancy periods. Female rabbits are sensitive to heat stress, which is considered an important factor influencing their reproduction, fertility and physiological traits [ 4 , 35 ]. Overall, heat stress and accompanying elevated oxidative stress increase the risk of spontaneous abortion and reduce milk production; litter size and litter performance; and the longevity, welfare, and health status of females.…”

Section: Discussionmentioning

confidence: 99%

“…Rabbit does are more susceptible to injury due to these effects as they exhibit critical physiological and hormonal changes during their reproductive cycles [ 3 , 4 ].The search for safe and effective naturally occurring feed supplements is considered to be a promising solution that can be applied to improve the harmful effects of heat stress. Phytochemicals are natural bioactive and non-nutritive plant chemicals that positively affect health [ 5 , 6 , 7 ].…”

Section: Introductionmentioning

confidence: 99%

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Effects of a Nanoencapsulated Moringa Leaf Ethanolic Extract on the Physiology, Metabolism and Reproductive Performance of Rabbit Does during Summer

et al. 2021

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This study investigated the effect of Moringa leaf ethanolic extract (MLEE) on heat-tolerance variables and the reproductive performance of rabbit does bred under hot climate conditions. Additionally, the effect of nanoencapsulation technology on the biological efficiency of MLEE was considered. A total of 56 rabbit does were randomly divided into four experimental groups and treated with 50 mg/kg body weight (BW) nonencapsulated MLEE, 25 or 10 mg/kg BW nanoencapsulated MLEE, or not treated (Control, C). The treatments continued for 50 days, including mating and pregnancy times. Physiological and hematochemical variables, hormonal profiles, and reproductive performance (kindling rate and litter characteristics) were determined. The active components of MLEE were identified. The results indicated that MLEE has 30 active components. All MLEE-based treatments reduced heat-stress-related indicators, such as rectal temperatures, respiratory rates and heart rate; improved hematochemical attributes, redox status, and hormones (progesterone and prolactin); and increased the total litter size, the kindling rate, litter size at birth and litter weight at birth. Adding MLEE can alleviate the negative impacts of heat stress by improving metabolism, redox status, and hormonal balance during pregnancy. These effects were seen whether MLLE was in free or encapsulated forms. However, the use of nanoencapsulated MLEE allowed 80% reduction (10 mg/kg BW) in the optimal dose (50 mg/kg BW) without affecting the efficiency of the treatment. These results support the importance of nanoencapsulation technology in improving the bioavailability of active components when they are orally administered.

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Pumpkin seed oil–supplemented diets promoted the growth productivity, antioxidative capacity, and immune response in heat-stressed growing rabbits

Abdelnour

Metwally

Bahgat

et al. 2023

Trop Anim Health Prod

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Heat stress is the most major environmental element contributing to rabbit health problems and reduced production. It is proposed that essential oils be applied to alleviate heat stress-induced oxidative damage in rabbits. The purpose of this feeding trial was to determine the protective impact of pumpkin seed essential oil (PSO)–supplemented diets in reducing the threat of unambient temperature on growing rabbits. Five groups of 5-week-old rabbits were allocated randomly into separated galvanized wire battery. The first group was raised under normal conditions (18 ± 2 °C) and fed a control diet (control group; CNT), whereas the other four groups were exposed to high ambient temperature (38 ± 2 °C) and fed a control diet supplemented with 0 (PSO0.0), 0.5 (PSO0.05), 1.0 (PSO1.0), and 2.0 (PSO2.0) mL PSO/kg diet. Results indicated that all supplemented groups and the positive control have higher live body weight compared with the heat stress group (PSO0.0) at 9 weeks of age. Supplementing of PSO resulted in significant improvement in weight gain at 5–9 weeks and 9–13 weeks compared with PSO0.0 group. The highest feed intake was detected in PSO0.05 group compared with that in other groups. Both PSO2.0 and PSO2.0 groups showed the lowest feed conversion ration compared with other groups. Heat-stressed rabbits given a high dose of PSO (1 to 2 mL) had higher hemoglobin concentrations and lower white blood cell counts throughout the experiment than those given a control diet and subjected to heat stress. All hepatic and renal function parameters improved significantly in the rabbits fed a high dose of PSO as compared to the heat-stressed control group, while protein constituents were significantly higher in experimental groups fed 2 mL PSO compared with other groups. Heat-stressed rabbits administered graded amounts of PSO had the lowest plasma glucose, cortisol, thyroid, and corticosterone concentrations and were noticed to be equivalent to the control group fed unsupplemented diet and reared under normal conditions. The immunohistochemistry analysis demonstrated that rabbit groups reared under heat stress and given 2 mL PSO supplemented diets had negative caspase-3 immunoreactivity surrounding portal tract and normal structure. In conclusion, adding pumpkin seed oil up to 2 mL/kg diet for growing rabbits is indorsed to promote growth as well as antioxidant and immunological status under heat stress conditions.

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Thermal stress causes oxidative stress and physiological changes in female rabbits

Cited by 22 publications

References 36 publications

Oxidative stress in osteomyelitis and burns: Specific features of its role in development of pathology

Oxidative stress in osteomyelitis and burns: Specific features of its role in development of pathology

Effects of a Nanoencapsulated Moringa Leaf Ethanolic Extract on the Physiology, Metabolism and Reproductive Performance of Rabbit Does during Summer

Pumpkin seed oil–supplemented diets promoted the growth productivity, antioxidative capacity, and immune response in heat-stressed growing rabbits

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