Thermal study of ethyl cellulose coating films used for modified release (MR) dosage forms

Regdon, Géza; Hegyesi, Diána; Pintye‐Hódi, Klára

doi:10.1007/s10973-011-1918-6

Cited by 14 publications

(5 citation statements)

References 18 publications

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“…They are appropriate to use (fibers or granules as basic materials) for the microencapsulation of drugs having short biological half-life but frequent administration. It is important the long-term stability of controlled-release dosage forms too [7,[41][42][43][44]. The indiscriminate use of antifungal agents has led to the advancement of microorganisms tolerant to the various drugs used in the market [45].…”

Section: Discussionmentioning

confidence: 99%

Differential thermal analysis of the antibacterial effect of PLA-based materials planned for 3D printing

Maróti

Kocsis

Ferencz

et al. 2019

J Therm Anal Calorim

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Additive manufacturing technologies give many new application possibilities in our everyday life. Biomedical applications benefit a lot from 3D printing. In medical applications, several devices can be easily produced or prototyped with FFF/ FDM technologies, but we must minimize the contamination risk. New materials regularly appear on the market, recently specified as antibacterial, resulting from compounded silver nanoparticles. Because scientifically accurate and practical information is not available, this way, we lack information regarding mechanical and thermal stability of the printed products. In addition, these parameters are essential in the setting and optimizing the 3D printers. In our recent study, we aimed to analyze PLA, PLA-HDT as well as PLA-Ag nanocomposite in the form of additive manufacturing filament, with DTA/TG. The results showed that these composites, based on their thermal characteristics, can be suitable for 3D print biomedical devices such as orthoses, casts, medical models and also surgical guides; therefore, their further examination should be important, regarding mechanical characteristics and their possible antibacterial effect.

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Section: Discussionmentioning

confidence: 99%

Differential thermal analysis of the antibacterial effect of PLA-based materials planned for 3D printing

Maróti

Kocsis

Ferencz

et al. 2019

J Therm Anal Calorim

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“…A nitrogen atmosphere was used (cell gas: 50 mL/min, method gas: 70 mL/min). Evaluation of the TG/DSC curves was performed with STAR e software (Mettler–Toledo GmbH, Budapest, Hungary) [ 39 ].…”

Section: Methodsmentioning

confidence: 99%

Manufacturing and Examination of Vaginal Drug Delivery System by FDM 3D Printing

et al. 2021

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Vaginal drug delivery systems can provide a long-term and constant liberation of the active pharmaceutical ingredient even for months. For our experiment, FDM 3D printing was used to manufacture the vaginal ring samples from thermoplastic polyurethane filament, which enables fast manufacturing of complex, personalized medications. 3D printing can be an excellent alternative instead of industrial manufacturing, which is complicated and time-consuming. In our work, the 3D printed vaginal rings were filled manually with jellified metronidazole or chloramphenicol for the treatment of bacterial vaginosis. The need for manual filling was certified by the thermogravimetric and heatflow assay results. The manufactured samples were analyzed by an Erweka USP type II Dissolution Apparatus, and the dissolution profile can be distinguished based on the applied jellifying agents and the API’s. All samples were considered non-similar based on the pairwise comparison. The biocompatibility properties were determined by prolonged MTT assay on HeLa cells, and the polymer could be considered non-toxic. Based on the microbiological assay on E. coli metronidazole and chitosan containing samples had bactericidal effects while just metronidazole or just chitosan containing samples bacteriostatic effect. None of these samples showed a fungistatic or fungicide effect against C. albicans. Based on our results, we successfully manufactured 3D printed vaginal rings filled with jellified metronidazole.

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“…Nitrogen atmosphere was used (Cell gas: 50 mL/min, method gas: 70 mL/min). Evaluation of the TG/DSC curves was performed with STAR e software (Mettler-Toledo GmbH, Budapest, Hungary) [ 76 ].…”

Section: Methodsmentioning

confidence: 99%

In Vitro Tests of FDM 3D-Printed Diclofenac Sodium-Containing Implants

et al. 2020

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One of the most promising emerging innovations in personalized medication is based on 3D printing technology. For use as authorized medications, 3D-printed products require different in vitro tests, including dissolution and biocompatibility investigations. Our objective was to manufacture implantable drug delivery systems using fused deposition modeling, and in vitro tests were performed for the assessment of these products. Polylactic acid, antibacterial polylactic acid, polyethylene terephthalate glycol, and poly(methyl methacrylate) filaments were selected, and samples with 16, 19, or 22 mm diameters and 0%, 5%, 10%, or 15% infill percentages were produced. The dissolution test was performed by a USP dissolution apparatus 1. A 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-2H-tetrazolium bromide dye (MTT)-based prolonged cytotoxicity test was performed on Caco-2 cells to certify the cytocompatibility properties. The implantable drug delivery systems were characterized by thermogravimetric and heatflow assay, contact angle measurement, scanning electron microscopy, microcomputed tomography, and Raman spectroscopy. Based on our results, it can be stated that the samples are considered nontoxic. The dissolution profiles are influenced by the material properties of the polymers, the diameter, and the infill percentage. Our results confirm the potential of fused deposition modeling (FDM) 3D printing for the manufacturing of different implantable drug delivery systems in personalized medicine and may be applied during surgical interventions.

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Thermal study of ethyl cellulose coating films used for modified release (MR) dosage forms

Cited by 14 publications

References 18 publications

Differential thermal analysis of the antibacterial effect of PLA-based materials planned for 3D printing

Differential thermal analysis of the antibacterial effect of PLA-based materials planned for 3D printing

Manufacturing and Examination of Vaginal Drug Delivery System by FDM 3D Printing

In Vitro Tests of FDM 3D-Printed Diclofenac Sodium-Containing Implants

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