Soluplus is an amphiphilic
graft copolymer intensively studied
as a micellar solubilizer for drugs. An extensive characterization
of the nanostructure of its colloidal aggregates is still lacking.
Here, we provide insights into the polymer’s self-assembly
in water, and we assess its use as an encapsulating agent for fragrances.
The self-assembly properties of Soluplus aqueous solutions were studied
over a wide concentration range (1–70% w/w) by means of small-angle
neutron scattering (SANS), differential scanning calorimetry, NMR,
and rheometry. SANS analyses revealed the presence of polymeric micelles
with a fuzzy surface interacting via a 2-Yukawa potential, up to 15%
w/w polymer. Increasing the polymer concentration up to 55% w/w led
to tightly packed micelles described according to the Teubner–Strey
model. The ability of Soluplus to encapsulate seven perfume molecules,
2-phenyl ethanol, l-carvone, linalool, florhydral, β-citronellol,
α-pinene, and R-limonene, was then examined.
We showed that the fragrance’s octanol/water partition coefficient
(log K
ow), widely used to characterize
the solubilization capacity, is not sufficient to characterize such
systems and the presence of specific functional groups or molecular
conformation needs to be considered. In fact, the combination of SANS,
NMR, confocal laser scanning microscopy, and confocal Raman microscopy
showed that the perfumes, interacting with different regions of the
polymer aggregates, are able to tune the systems’ structures
resulting in micelles, matrix-type capsules, core–shell capsules,
or oil-in-water emulsions.