Thermal Undulations of Lipid Bilayers Relax by Intermonolayer Friction at Submicrometer Length Scales

Shkulipa, S.; Otter, Wouter K. den; Briels, Willem J.

doi:10.1103/physrevlett.96.178302

Cited by 48 publications

(54 citation statements)

References 37 publications

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“…The values we find for b, i.e., b = 2 − 8 × 10 8 J.s/m 4 (see Fig. 9), are in good agreement with the literature [34,35]. Besides, we can see on Fig.…”

Section: Measurement Of the Intermonolayer Friction Coefficient B Andsupporting

confidence: 91%

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Dynamical membrane curvature instability controlled by intermonolayer friction

Bitbol

Fournier

Angelova

et al. 2011

J. Phys.: Condens. Matter

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Abstract. We study a dynamical curvature instability caused by a local chemical modification of a phospholipid membrane. In our experiments, a basic solution is microinjected close to a giant unilamellar vesicle, which induces a local chemical modification of some lipids in the external monolayer of the membrane. This modification causes a local deformation of the vesicle, which then relaxes. We present a theoretical description of this instability, taking into account both the change of the equilibrium lipid density and the change of the membrane spontaneous curvature induced by the chemical modification. We show that these two types of changes of the membrane properties yield different dynamics. In contrast, it is impossible to distinguish them when studying the equilibrium shape of a vesicle submitted to a global modification. In our model, the longest relaxation timescale is related to the intermonolayer friction, which plays an important part when there is a change of the equilibrium density in one monolayer. We compare our experimental results to the predictions of our model by fitting the measured time evolution of the deformation height to the solution of our dynamical equations. We obtain a good agreement between theory and experiments. Our fits enable us to estimate the intermonolayer friction coefficient, yielding values consistent with previous measurements.

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“…The values we find for b, i.e., b = 2 − 8 × 10 8 J.s/m 4 (see Fig. 9), are in good agreement with the literature [34,35]. Besides, we can see on Fig.…”

Section: Measurement Of the Intermonolayer Friction Coefficient B Andsupporting

confidence: 91%

“…Its last term is the normal viscous stress exerted by the flow of the surrounding fluid, the normal velocity of which matches ∂h/∂t on the membrane. Finally, Equation (25) [34,35]. Comparing these dynamical equations with the ones of Ref.…”

Section: Hydrodynamic Equationsmentioning

confidence: 83%

Dynamical membrane curvature instability controlled by intermonolayer friction

Bitbol

Fournier

Angelova

et al. 2011

J. Phys.: Condens. Matter

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show abstract

“…The proximity of another surface, [14] the presence of an external potential, [15] an imposed tension, [16,17] the presence of active components [18][19][20] or geometrical confinement [21] all modify these fluctuations. The problem of membrane fluctuations has been studied theoretically for a long time, [14,15,[22][23][24] see also ref. [25] for a review of early work.…”

Section: Introductionmentioning

confidence: 99%

Probing Biomembrane Dynamics by Dual‐Wavelength Reflection Interference Contrast Microscopy

Monzel¹,

Fenz²,

Merkel³

et al. 2009

ChemPhysChem

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We present an improved analysis of reflection interference contrast microscopy (RICM) images, recorded to investigate model membrane systems that mimic cell adhesion. The model systems were giant unilamellar vesicles (GUV) adhering via specific ligand-receptor interactions to supported lipid bilayers (SLB) or to patterns of receptors. Conventional RICM and dual-wavelength RICM (DW-RICM) were applied to measure absolute optical distances between the biomembranes and planar substrates. We developed algorithms for a straightforward implementation of an automated, time-resolved reconstruction of the membrane conformations from RICM/DW-RICM images, taking into account all the interfaces in the system and blurring of the data due to camera noise. Finally, we demonstrate the validity and usefulness of this new approach by analyzing the topography and fluctuations of a bound membrane in the steady state and its dynamic adaptation to osmotic pressure changes. These measurements clearly show that macroscopic membrane flow through tightly adhered area is possible in our system.

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“…The amplitudes and relaxation times of the experimental S lm will most likely also contain information on the mechanical properties of the cage, like its elasticity and bending rigidity 2 , in a convoluted manner. An analysis along these lines, as has been achieved for the undulations of a lipid membrane [176,179], exceeds the objectives of the current study. To the best of our knowledge, these large scale modes of entire clathrin cages have not been studied previously.…”

Section: Resultsmentioning

confidence: 99%

Chameleon behaviour of a-synuclein : brownian dynamics simulations of protein aggregation

Ilie

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Thermal Undulations of Lipid Bilayers Relax by Intermonolayer Friction at Submicrometer Length Scales

Cited by 48 publications

References 37 publications

Dynamical membrane curvature instability controlled by intermonolayer friction

Dynamical membrane curvature instability controlled by intermonolayer friction

Probing Biomembrane Dynamics by Dual‐Wavelength Reflection Interference Contrast Microscopy

Chameleon behaviour of a-synuclein : brownian dynamics simulations of protein aggregation

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