Thermally Crosslinked Biocompatible Hydrophilic Polyvinylpyrrolidone Coatings on Polypropylene with Enhanced Mechanical and Adhesion Properties

Jang, Hayeong; Choi, Hyungjoon; Jeong, Heejeong; Baek, Seolhee; Han, Singu; Chung, Dong June; Lee, Hwa Sung

doi:10.1007/s13233-018-6031-2

Cited by 15 publications

(8 citation statements)

References 36 publications

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“…The shape of the microneedles in our study was faceted pyramidal due to the use of the pyramidal PDMS mold in the microneedle preparation. The faceted appearance of the CIP_MN1 and CIP_MN2 microneedles was attributed to the shrinkage of the polymer gel upon drying as suggested by previous studies [32,33]. A similarly faceted shape of microneedles was observed with polymeric microneedles made of chitosan and alginate [34].…”

Section: Microneedles Characterizationsupporting

confidence: 71%

Ciprofloxacin-loaded dissolving polymeric microneedles as a potential therapeutic for the treatment of S. aureus skin infections

Abdelghany¹,

Alshaer²,

Thaher³

et al. 2022

Beilstein J. Nanotechnol.

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Microneedles have been widely studied for many topical and transdermal therapeutics due to their ability to painlessly puncture the skin, thereby bypassing the stratum corneum, the main skin barrier. In this study, ciprofloxacin (CIP) was loaded into dissolving polymeric microneedles prepared by a two-layer centrifugation method as a potential treatment of skin infections such as cellulitis. The polymers used were polyvinyl alcohol (PVA) and polyvinylpyrrolidone (PVP). Two formulations were investigated, namely CIP_MN1, composed of 10 mg ciprofloxacin incorporated into a polymer matrix of PVA and PVP with a weight ratio of (9:1), and CIP_MN2, composed of 10 mg ciprofloxacin incorporated into PVA polymer. CIP_MN1 and CIP_MN2 showed a mean microneedle height of 188 and 179 µm, respectively. Since Parafilm has been proven as a model to examine the perforation of microneedles in skin, it was used to evaluate the ability of microneedles to perforate the skin. CIP_MN1 showed almost complete perforation of Parafilm, 190 pores, compared to CIP_MN2 which created only 85 pores in Parafilm, and therefore CIP_MN1 was used for subsequent studies. Examining CIP_MN1 on agarose gel as an in vitro model of human skin showed that the formula was able to fully perforate the agarose gel. Moreover, this formula showed significantly greater antimicrobial activity (p < 0.0001) compared to a free gel of ciprofloxacin against Staphylococcus aureus in an agarose gel-based model. This was evidenced by a zone of inhibition of 29 mm for the microneedle formulation of ciprofloxacin (CIP_MN1) compared to 2 mm for the free gel of ciprofloxacin. Furthermore, the CIP_MN1 showed complete dissolution in human skin after 60 min from application. Finally, the skin deposition of CIP_MN1 was investigated in ex vivo excised human skin. CIP_MN1 showed significantly more deposition of ciprofloxacin in deeper skin layers compared to the free gel of ciprofloxacin, and the released ciprofloxacin from the microneedles tends to migrate to deeper layers with time. Collectively, these results suggest that CIP_MN1 can be a potential delivery system for the treatment of S. aureus skin infections.

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Section: Microneedles Characterizationsupporting

confidence: 71%

Ciprofloxacin-loaded dissolving polymeric microneedles as a potential therapeutic for the treatment of S. aureus skin infections

Abdelghany¹,

Alshaer²,

Thaher³

et al. 2022

Beilstein J. Nanotechnol.

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“…Apart from various surface modification techniques, the molecular composition present inside polymer coatings is one of the factors affecting mechanical strength [ 167 ]. Through thermal cross-linking of polymer coating, a polyvinyl pyrrolidone (PVP) chain, stabilized with a polyethyleneglycoldiacrylate (PEGDA) cross-linked matrix onto a polymer substrate, polypropylene (PP) was developed with enhanced adhesion strength [ 10 ]. A different blend ratio of PEGDA–PVP played an important role in influencing the adhesion strength of a coating; as the proportion of PEGDA increased, the adhesion strength and flexibility of coating also increased, while coating hardness decreased until it reached maximum strength value when PEGDA was in excess.…”

Section: Surface Properties For Antimicrobial Surface Coatingmentioning

confidence: 99%

“…In the medical and health fields, microbial contamination of medical devices may occur before or after implantation, which presents a significant challenge for the treatment of contaminated medical devices. Thus, the antimicrobial coating has been widely used in medical device manufacturing to prevent problems related to medical device-associated infections [ 9 , 10 , 11 ].…”

Section: Introductionmentioning

confidence: 99%

Past and Current Progress in the Development of Antiviral/Antimicrobial Polymer Coating towards COVID-19 Prevention: A Review

et al. 2021

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The astonishing outbreak of SARS-CoV-2 coronavirus, known as COVID-19, has attracted numerous research interests, particularly regarding fabricating antimicrobial surface coatings. This initiative is aimed at overcoming and minimizing viral and bacterial transmission to the human. When contaminated droplets from an infected individual land onto common surfaces, SARS-CoV-2 coronavirus is able to survive on various surfaces for up to 9 days. Thus, the possibility of virus transmission increases after touching or being in contact with contaminated surfaces. Herein, we aim to provide overviews of various types of antiviral and antimicrobial coating agents, such as antimicrobial polymer-based coating, metal-based coating, functional nanomaterial, and nanocomposite-based coating. The action mode for each type of antimicrobial agent against pathogens is elaborated. In addition, surface properties of the designed antiviral and antimicrobial polymer coating with their influencing factors are discussed in this review. This paper also exhibits several techniques on surface modification to improve surface properties. Various developed research on the development of antiviral/antimicrobial polymer coating to curb the COVID-19 pandemic are also presented in this review.

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“…To tackle the high hydrophobicity of the PP surface, Jang et al [ 61 ] developed a matrix combining polyvinyl pyrrolidone (PVP) and cross-linked polyethyleneglycolacrylate (PEGDA) to produce a stable hydrogel forming layer (PVP:PEGDA) that exhibited hydrophilicity and bioactivity. This study revealed that the hydrophilic nature of the film improved, and the mechanical as well as adhesive strength of the PP surface could be optimized by adjusting the PVP and PEGDA ratio.…”

Section: Biopolymer Coatings For Surface Modificationmentioning

confidence: 99%

Biopolymer Coatings for Biomedical Applications

Nathanael

2020

Polymers

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Biopolymer coatings exhibit outstanding potential in various biomedical applications, due to their flexible functionalization. In this review, we have discussed the latest developments in biopolymer coatings on various substrates and nanoparticles for improved tissue engineering and drug delivery applications, and summarized the latest research advancements. Polymer coatings are used to modify surface properties to satisfy certain requirements or include additional functionalities for different biomedical applications. Additionally, polymer coatings with different inorganic ions may facilitate different functionalities, such as cell proliferation, tissue growth, repair, and delivery of biomolecules, such as growth factors, active molecules, antimicrobial agents, and drugs. This review primarily focuses on specific polymers for coating applications and different polymer coatings for increased functionalization. We aim to provide broad overview of latest developments in the various kind of biopolymer coatings for biomedical applications, in order to highlight the most important results in the literatures, and to offer a potential outline for impending progress and perspective. Some key polymer coatings were discussed in detail. Further, the use of polymer coatings on nanomaterials for biomedical applications has also been discussed, and the latest research results have been reported.

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Thermally Crosslinked Biocompatible Hydrophilic Polyvinylpyrrolidone Coatings on Polypropylene with Enhanced Mechanical and Adhesion Properties

Cited by 15 publications

References 36 publications

Ciprofloxacin-loaded dissolving polymeric microneedles as a potential therapeutic for the treatment of S. aureus skin infections

Ciprofloxacin-loaded dissolving polymeric microneedles as a potential therapeutic for the treatment of S. aureus skin infections

Past and Current Progress in the Development of Antiviral/Antimicrobial Polymer Coating towards COVID-19 Prevention: A Review

Biopolymer Coatings for Biomedical Applications

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