Thermally drawn biodegradable fibers with tailored topography for biomedical applications

Farajikhah, Syamak; Runge, Antoine F. J.; Boumelhem, Badwi B.; Rukhlenko, Ivan D.; Stefani, Alessio; Sayyar, Sepidar; Innis, Peter C.; Fraser, Stuart T.; Fleming, Simon; Large, M. I.

doi:10.1002/jbm.b.34739

Cited by 17 publications

(9 citation statements)

References 38 publications

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“…The resulting implant adhesion (shear) strength remains to be improved by a factor of 10–100× for load-bearing applications, but may suit less-strenuous, non-load-bearing applications. Our future work will continue to improve the adhesion strength of light-activated bone implants while expanding the technology to the latest materials available for transparent waveguides. − In vivo investigation of CaproGlu has previously demonstrated moderate immunological response . CaproGlu was also assessed by OECD-regulated in vitro tests, which demonstrated no sensitization or genotoxic effect .…”

Section: Results and Discussionmentioning

confidence: 99%

Fixation of Transparent Bone Pins with Photocuring Biocomposites

Wicaksono

Toni

Tok

et al. 2021

ACS Biomater. Sci. Eng.

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Bone fractures are in need of rapid fixation methods, but the current strategies are limited to metal pins and screws, which necessitate secondary surgeries upon removal. New techniques are sought to avoid surgical revisions, while maintaining or improving the fixation speed. Herein, a method of bone fixation is proposed with transparent biopolymers anchored in place via light-activated biocomposites based on expanding CaproGlu bioadhesives. The transparent biopolymers serve as a UV light guide for the activation of CaproGlu biocomposites, which results in evolution of molecular nitrogen (from diazirine photolysis), simultaneously expanding the covalently cross-linked matrix. Osseointegration additives of hydroxyapatite or Bioglass 45S5 yield a biocomposite matrix with increased stiffness and pullout strength. The structure−property relationships of UV joules dose, pin diameter, and biocomposite additives are assessed with respect to the apparent viscosity, shear modulus, spatiotemporal pin curing, and lap-shear adhesion. Finally, a model system is proposed based on ex vivo investigation with bone tissue for the exploration and optimization of UV-active transparent biopolymer fixation.

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Section: Results and Discussionmentioning

confidence: 99%

Fixation of Transparent Bone Pins with Photocuring Biocomposites

Wicaksono

Toni

Tok

et al. 2021

ACS Biomater. Sci. Eng.

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“…3D printing, electrospinning, melt spinning are commonly used to fabricate scaffold structures. [ 62–68 ] Most recently, the reinforcing of biopolymers with various fillers, such as metal oxides, hydroxyapatite, nanocrystals, and many others, to develop implants and scaffolds has become a research hotspot. Implants and scaffolds require materials that possess a high load‐bearing capability.…”

Section: Applications Of Biopolymersmentioning

confidence: 99%

“…Most synthetic biopolymers and their composites are used in tissue engineering, [ 54–68,73,75–78 ] as evident from Table 1. Besides tissue engineering, studies have targeted possible applications in drug delivery, [ 69–72 ] implants, [ 74 ] and wound healing.…”

Section: Applications Of Biopolymersmentioning

confidence: 99%

“…[ 58,59,61,68,70 ] The electrospun PCL fibers were also shown effective in supporting cell growth and proliferation of MCF‐7 breast cancer. [ 64 ] Other studies have investigated the potential application of PLA containing chitin and lignin for the implant and healing application. [ 74,79,80 ] The tensile and elongation at break were decreasing with lignin loading; however, the cell metabolic activity was not altered.…”

Section: Applications Of Biopolymersmentioning

confidence: 99%

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Synthetic Biopolymers and Their Composites: Advantages and Limitations—An Overview

Mtibe

Motloung

Bandyopadhyay

et al. 2021

Macromol. Rapid Commun.

110

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Recently, polymer science and engineering research has shifted toward the development of environmentally benign polymers to reduce the impact of plastic leakage on the ecosystems. Stringent regulations and concerns regarding conventional polymers are the main driving forces for the development of renewable, biodegradable, sustainable, and environmentally benign materials. Although biopolymers can alleviate plastic‐related pollution, several factors dictate the utilization of biopolymers. Herein, an overview of the potential and limitations of synthetic biopolymers and their composites in the context of environmentally benign materials for a sustainable future are presented. The synthetic biopolymer market, technical advancements for different applications, lifecycle analysis, and biodegradability are covered. The current trends, challenges, and opportunities for bioplastic recycling are also discussed. In summary, this review is expected to provide guidelines for future development related to synthetic biopolymer‐based sustainable polymeric materials suitable for various applications.

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“…S. Farajikhah et al [ 58 ] demonstrated the fabrication of PCL based optical fiber with tailored cross-sections, such as unclad solid-core filaments, hollow-core, and grooved fibers, all thermally drawn from preforms. The PCL preforms were prepared by melting PCL pellets at 80 °C for 17 h inside polypropylene and Teflon ® molds of various shapes.…”

Section: Optical Fiber Fabrication Techniquesmentioning

confidence: 99%

Challenges in the Fabrication of Biodegradable and Implantable Optical Fibers for Biomedical Applications

et al. 2021

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The limited penetration depth of visible light in biological tissues has encouraged researchers to develop novel implantable light-guiding devices. Optical fibers and waveguides that are made from biocompatible and biodegradable materials offer a straightforward but effective approach to overcome this issue. In the last decade, various optically transparent biomaterials, as well as different fabrication techniques, have been investigated for this purpose, and in view of obtaining fully fledged optical fibers. This article reviews the state-of-the-art in the development of biocompatible and biodegradable optical fibers. Whilst several reviews that focus on the chemical properties of the biomaterials from which these optical waveguides can be made have been published, a systematic review about the actual optical fibers made from these materials and the different fabrication processes is not available yet. This prompted us to investigate the essential properties of these biomaterials, in view of fabricating optical fibers, and in particular to look into the issues related to fabrication techniques, and also to discuss the challenges in the use and operation of these optical fibers. We close our review with a summary and an outline of the applications that may benefit from these novel optical waveguides.

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Thermally drawn biodegradable fibers with tailored topography for biomedical applications

Cited by 17 publications

References 38 publications

Fixation of Transparent Bone Pins with Photocuring Biocomposites

Fixation of Transparent Bone Pins with Photocuring Biocomposites

Synthetic Biopolymers and Their Composites: Advantages and Limitations—An Overview

Challenges in the Fabrication of Biodegradable and Implantable Optical Fibers for Biomedical Applications

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