Thermally induced interactions between adamantan-2-one and some pharmaceutical excipients

Vlase, Gabriela; Budiul, Mihaela; Vlase, Titus; Albu, Paul; Ledeţi, Adriana

doi:10.1007/s10973-017-6332-2

“…Several processes can be observed on the HF curve, namely, an exothermic process with a maximum at 230 °C with a loss of 69.26% of the sample mass, followed by an endothermic process with a maximum at 260 °C with a loss of 21.58%. Te literature suggests that ampicillin monohydrate exhibits a melting process that begins with the decomposition of the sample [36][37][38][39][40][41][42][43][44][45][46][47][48][49][50][51][52][53][54].…”

Section: Termal Analysis Of Active Substances and Binarymentioning

confidence: 99%

“…During the obtaining new bone-grafting materials, it is very important to know the physicochemical properties of drugs and the individual components. Te studies presented in the literature prove that thermal analysis techniques are methods used for the physicochemical characterization of various materials used in pharmaceutical and other felds [37][38][39][40][41][42][43][44][45][46][47]. In the present paper, by combining the complementary physicochemical techniques, TG/DTG/HF, FTIR-UATR, UV-Vis ultraviolet-visible, and SEM-EDX, it is determined which is the best bone-grafting material that can be used to release the analyzed active ingredients individually and in the form of a mixture.…”

Section: Introductionmentioning

confidence: 99%

Dental Biopolymer Composites with Antibiotics, Bisphosphonate, and Hydroxyapatite for Possible Use in Bone Tissue Regeneration

Budiul,

Vlase,

Negru

et al. 2024

Journal of Chemistry

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The aim of the present study was to formulate new variants of synthetic and animal-source bone materials coated with different biopolymers, containing antibiotics (ampicillin and oxacillin) and alendronate drugs. Validation consists in establishing mixtures that do not present interactions between components. These materials should act as a drug delivery system alongside the bone base. Natural polymers such as chitosan, alginate, and kappa-carrageenan have been shown to be optimal materials for drug delivery due to their intrinsic biocompatibility. Binary, ternary, and quaternary mixtures between components are analyzed by FT-IR spectroscopy, UV-Vis analysis, thermogravimetry (TGA), and scanning electron microscopy (SEM). The analysis led to the validation of materials suitable for the controlled release of active substances, which have the greatest chance of increasing the speed of bone regeneration, as well as helping in the local administration of antibiotics, which currently must be administered in the form of oral formulations or an injection. According to the FTIR, thermogravimetry, UV-Vis, SEM, and cytotoxicity tests performed in this study, it can be said that it is quite easy to obtain materials that can be used in dental practice that facilitate bone reconstruction through local treatment. At the same time, it was found that both active substances can be incorporated into the material together with Alg and Chit, thus limiting the adverse effects and maximizing the local beneficial effects.

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“…Several processes can be observed on the HF curve, namely, an exothermic process with a maximum at 230 °C with a loss of 69.26% of the sample mass, followed by an endothermic process with a maximum at 260 °C with a loss of 21.58%. Te literature suggests that ampicillin monohydrate exhibits a melting process that begins with the decomposition of the sample [36][37][38][39][40][41][42][43][44][45][46][47][48][49][50][51][52][53][54].…”

Section: Termal Analysis Of Active Substances and Binarymentioning

confidence: 99%

“…During the obtaining new bone-grafting materials, it is very important to know the physicochemical properties of drugs and the individual components. Te studies presented in the literature prove that thermal analysis techniques are methods used for the physicochemical characterization of various materials used in pharmaceutical and other felds [37][38][39][40][41][42][43][44][45][46][47]. In the present paper, by combining the complementary physicochemical techniques, TG/DTG/HF, FTIR-UATR, UV-Vis ultraviolet-visible, and SEM-EDX, it is determined which is the best bone-grafting material that can be used to release the analyzed active ingredients individually and in the form of a mixture.…”

Section: Introductionmentioning

confidence: 99%