Thermo- and light-regulated fluorescence resonance energy transfer processes within dually responsive microgels

Yin, Jun; Hu, Haibo; Wu, Yonghao; Liu, Shiyong

doi:10.1039/c0py00254b

Cited by 89 publications

(66 citation statements)

References 78 publications

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“…Recently, there has been increased interest in polymers that respond to a variety of other stimuli that have been less frequently considered 4, 10. Specifically, to enable access to stimuli‐responsive materials for many biomedical applications, it is important to prepare polymers that respond to specific chemical stimuli encountered in vivo .…”

Section: Introductionmentioning

confidence: 99%

Tuning the sugar‐response of boronic acid block copolymers

Cambre¹,

Roy²,

Sumerlin³

2012

J. Polym. Sci. A Polym. Chem.

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A detailed study of the pH‐ and sugar‐responsive behavior of poly(3‐acrylamidophenylboronic acid pinacol ester)‐b‐poly(N,N‐dimethylacrylamide) (PAPBAE‐b‐PDMA) block copolymers is presented. Reversible addition‐fragmentation chain transfer (RAFT) polymerization of the pinacol ester of 3‐acrylamidophenylboronic acid resulted in homopolymers with molecular weights between 12,000 and 37,000 g/mol. The resulting homopolymers were employed as macro‐chain transfer agents during the polymerization of N,N‐dimethylacrylamide (DMA). Successful chain extension and removal of the pinacol protecting groups to yield poly(3‐acrylamidophenylboronic acid)‐b‐PDMA (PAPBA‐b‐PDMA) with free boronic acid moieties resulted in pH‐ and sugar‐responsive block copolymers that were subsequently investigated for their behavior in aqueous solution. The PAPBA‐b‐PDMA block copolymers were capable of solution self‐assembly due to the PAPBA block being water‐insoluble below its pKa. The resulting aggregates were demonstrated to solubilize and release model hydrophobic compounds, as demonstrated by fluorescence studies. Dissociation of the aggregates was induced by raising the pH above the pKa of the boronic acid residues or by adding sugars capable of forming boronate esters. Aggregate size, dissociation kinetics, and the effect of various sugars were considered. The critical sugar concentration needed to induce aggregate dissociation was tuned by incorporation of hydrophilic DMA units within the PAPBA responsive segment to yield PDMA‐b‐poly(3‐acrylamidophenylboronic acid‐co‐DMA) block copolymers. © 2012 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem, 2012

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Section: Introductionmentioning

confidence: 99%

Tuning the sugar‐response of boronic acid block copolymers

Cambre¹,

Roy²,

Sumerlin³

2012

J. Polym. Sci. A Polym. Chem.

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“…In recent years, much effort has been paid on the design and development of the PNIPAM‐based fluorescent chemosensors due to its reversible thermoresponsive property . In current study, the reversible thermoresponsive behavior of shell PNIPAM should result in the change of fluorescence emission of nanoparticles at different temperatures.…”

Section: Resultsmentioning

confidence: 89%

Design and property of thermoresponsive core-shell fluorescent nanoparticles via RAFT polymerization and suzuki coupling reaction

Xing

Zhang

et al. 2013

J. Polym. Sci. Part A: Polym. Chem.

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The polymerization of a 2,7-dibromocarbazole-containing functional monomer, 6-(2,7-dibromo-9H-carbazol-9yl)hexyl methacrylate (DBCzMA), was successfully carried out via the reversible addition-fragmentation chain transfer (RAFT) technology. The polymerization behavior possessed the feature of "living"/controlled radical polymerization, for example, the first-order kinetics, the linear increase of the molecular weight of the polymer with the monomer conversion and relatively narrow molecular weight distribution (M w /M n 1.27). The amphiphilic copolymers, poly(DBCzMA m -b-NIPAM n ), with different chain length of poly(DBCzMA) and poly(N-isopropylacrylamide) (PNIPAM), were successfully prepared via RAFT chainextension reaction, using poly(DBCzMA) as the macromolecular chain transfer agent (macro-CTA) and NIPAM as the second monomer. Modification of 2,7-dibromide groups in amphiphilic copolymer poly(DBCzMA-b-NIPAM) via Suzuki coupling reaction employed 2,7-bis(4 0 ,4 0 ,5 0 ,5 0 -tetramethyl-1 0 ,3 0 ,2 0 -dioxaborolan-2 0 -yl)-N29 00 -heptadecanylcarbazole as the other reaction material to afford a poly(2,7-carbazole)-containing crosslinked materials. The stable and uniform core-shell fluorescent nanoparticles were successfully prepared in water. The formed fluorescent nanoparticles showed good thermoresponsive properties, which is confirmed by dynamic light scattering observation.

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“…The overlap of the emission spectrum of PDSEA and the absorption spectrum of Flu indicates that PDSEA and Flu can act as the donor and acceptor for FRET (Figure S9, Supporting Information). As can be seen from the fluorescence spectra of the precursor polymers (Figure S10a, Supporting Information) and the CL nanogels (Figure S10b, Supporting Information), excited at 416 nm as a function of temperature, at low temperatures the emission mainly originates from the PDS units at 486 nm with a weak emission at 514 nm from FRET between PDS and Flu . The fluorescence intensity ratio, I 486 / I 514 , shows an abrupt drop on heating to 37 °C for the precursor polymers (Figure S11a, Supporting Information) but a continuous reduction for the CL nanogels (Figure S11b, Supporting Information), which is consistent with characteristics of the thermoresponsive properties of the precursor polymers and CL nanogels as revealed by the turbidity and DLS studies.…”

Section: Resultsmentioning

confidence: 94%

Switching between Polymer Architectures with Distinct Thermoresponses

Sun

2017

Macromol. Rapid Commun.

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Thermoresponsive linear polymers and their corresponding aggregates or nanogels typically show similar thermoresponsive profiles. In this study, the authors demonstrate reversible chemical switching between linear polymers and their cross-linked nanogels. The linear polymers exhibit sharp thermal transitions typical of common thermoresponsive polymers but the cross-linked nanogels exhibit "linear" thermal transitions over a relatively broad temperature range. The reversible switching between these two different polymer architectures with distinct thermoresponses represents a unique example of how the responsive properties of smart polymers can be significantly manipulated via polymer architecture engineering.

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Thermo- and light-regulated fluorescence resonance energy transfer processes within dually responsive microgels

Cited by 89 publications

References 78 publications

Tuning the sugar‐response of boronic acid block copolymers

Tuning the sugar‐response of boronic acid block copolymers

Design and property of thermoresponsive core-shell fluorescent nanoparticles via RAFT polymerization and suzuki coupling reaction

Switching between Polymer Architectures with Distinct Thermoresponses

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