Thermo- and pH-responsive polymers in drug delivery☆

Schmaljohann, Dirk

doi:10.1016/j.addr.2006.09.020

Cited by 2,821 publications

(2,053 citation statements)

References 100 publications

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“…The rapid pH-mediated changes in I 338 /I 333 can be ascribed to a pH-dependent coil-to-globule transition of polymer conformation. 25 At pH 7.4, the polymer displayed an expanded structure due to the electrostatic repulsion between negatively charged carboxylate ions. Upon acidification, the carboxylate groups were protonated and hydrophobic association became predominant, leading to the formation of a compact structure with the hydrophobic core where pyrene was preferentially solubilized.…”

Section: Aqueous Solution Propertiesmentioning

confidence: 99%

Membrane-Anchoring, Comb-Like Pseudopeptides for Efficient, pH-Mediated Membrane Destabilization and Intracellular Delivery

Chen

Wang

Kopytynski

et al. 2017

ACS Appl. Mater. Interfaces

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Endosomal release has been identified as a rate-limiting step for intracellular delivery of therapeutic agents, in particular macromolecular drugs. Herein, we report a series of synthetic pH-responsive, membrane-anchoring polymers exhibiting dramatic endosomolytic activity for efficient intracellular delivery. The comb-like pseudopeptidic polymers were synthesized by grafting different amounts of decylamine (NDA), which act as hydrophobic membrane anchors, onto the pendant carboxylic acid groups of a pseudopeptide, poly (L-lysine isophthalamide). The effects of the hydrophobic relatively long alkyl side chains on aqueous solution properties, cell membrane destabilization activity and in-vitro cytotoxicity were investigated. The optimal polymer containing 18 mol% NDA exhibited limited hemolysis at pH 7.4, but induced nearly complete membrane destabilization at endosomal pH within only 20 min. The mechanistic investigation of membrane destabilization suggests the polymermediated pore formation. It has been demonstrated that the polymer with hydrophobic side chains displayed a considerable endosomolytic ability to release endocytosed materials into the cytoplasm of various cell lines, which is of critical importance for intracellular drug delivery applications.

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Section: Aqueous Solution Propertiesmentioning

confidence: 99%

Membrane-Anchoring, Comb-Like Pseudopeptides for Efficient, pH-Mediated Membrane Destabilization and Intracellular Delivery

Chen

Wang

Kopytynski

et al. 2017

ACS Appl. Mater. Interfaces

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“…Recently, responsive material printing has emerged as a promising method to print simple patterns/structures first and then deform into complex structures upon different stimuli. Such responsive material-based fabrication strategy is widely adopted for biomedical applications such as drug delivery systems [21,22,29,30] and artificial muscles [31], to name a few. In this study two nanoclay-enabled responsive materials (NIPAAm-Laponite and NIPAAm-Laponite-GO precursors [25]) were printed to fabricate a three-layered 1D pattern (Fig.…”

Section: Nanocomposite Hydrogel Direct Printing Applicationmentioning

confidence: 99%

“…In this study, N -isopropylacrylamide (NIPAAm) is selected as a model ink material with poor extrudability. As a thermally sensitive hydrogel precursor, NIPAAm has been extensively investigated for various biological applications such as drug delivery [21,22] since its deformation can be triggered by physiological temperature conditions. To investigate the influence of nanoclay additive during nanoclay-enabled direct extrusion printing, Laponite XLG nanoclay is used as both ink material and internal scaffold material.…”

mentioning

confidence: 99%

Study of extrudability and standoff distance effect during nanoclay-enabled direct printing

2018

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Nanoclay-enabled self-supporting printing has been emerging as a promising filament-based extrusion fabrication approach for different biomedical and engineering applications including tissue engineering. With the addition of nanoclay powders, liquid build materials may exhibit solid-like behavior upon extrusion and can be directly printed in air into complex three-dimensional structures. The objective of this study is to investigate the effect of nanoclay on the extrudability of N -isopropylacrylamide (NIPAAm) and the effect of standoff distance on the print quality during nanoclay-enabled direct printing. It is found that the addition of nanoclay can significantly improve the NIPAAm extrudability and effectively eliminate die swelling in material extrusion. In addition, with the increase of standoff distance, deposited filaments change from over-deposited to well-defined to stretched to broken, the filament width decreases, and the print fidelity deteriorates. A mathematical model is further proposed to determine the optimal standoff distance to achieve better print fidelity during nanoclay-enabled direct printing. Based on the extrudability and standoff distance knowledge from this study, NIPAAm-Laponite nanoclay and NIPAAm-Laponite nanoclay-graphene oxide nanocomposite hydrogel precursors are successfully printed into a three-layered one-dimensional responsive pattern, demonstrating the good extrudability and print quality during nanoclay-enabled printing under optimal printing conditions.

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“…Here, NIR absorbing HGNs with an average outer diameter of ∼43.5 nm and a shell thickness of 3-4 nm were stabilized with polyethylene glycol (PEG) and attached to an ∝-melanocyte-stimulating hormone (MSH) analog, [Nle4,D-Phe7]a-MSH (NDP-MSH), targeting the melanocortin type-1 receptor over-expressed in melanoma. PEG has shown to be the most effective capping agent for HGNs, stabilizing the nanoparticles against aggregation, caused by both increased salt concentration (up to 5 M) and changes in pH [222,223]. The intracellular uptake of bioconjugated HGNs was confirmed by both excised tissue and by (18F)-fluorodeoxyglucose positron emission tomography [72].…”

Section: Pta With Hgnsmentioning

confidence: 98%

Controllable Cobalt Oxide/Au Hierarchically Nanostructured Electrode for Nonenzymatic Glucose Sensing

2016

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By electrodeposition and galvanic replacement reaction, we developed a facile, time-saving, cost-effective, and environmentally friendly, two-step synthesis route to obtain a controllable cobalt oxide/Au hierarchically nanostructured electrode for glucose sensing. The nanomaterials were characterized by transmission electron microscopy, scanning electron microscopy, Raman spectroscopy, energy-dispersive spectrometry, and X-ray photoelectron spectroscopy, meanwhile, the sensing performance was investigated by cyclic voltammetry and amperometric response. The results revealed that this novel electrode exhibited excellent electrocatalytic performance toward glucose oxidation, with a wide double-linear range from 0.2 μM to 20 mM and a low detection limit of 0.1 μM based on a signal-to-noise ratio of 3, which was mainly attributed to the ability of loading a small amount of Au with good electron conductivity on the surface of cobalt oxide nanosheets with large active surface area and synergistic electrocatalytic activity of Au and cobalt oxide toward glucose electrooxidation. This facile, sensitive, and selective glucose sensor is also proven to be suitable for the detection of glucose in human serum.

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Thermo- and pH-responsive polymers in drug delivery☆

Cited by 2,821 publications

References 100 publications

Membrane-Anchoring, Comb-Like Pseudopeptides for Efficient, pH-Mediated Membrane Destabilization and Intracellular Delivery

Membrane-Anchoring, Comb-Like Pseudopeptides for Efficient, pH-Mediated Membrane Destabilization and Intracellular Delivery

Study of extrudability and standoff distance effect during nanoclay-enabled direct printing

Controllable Cobalt Oxide/Au Hierarchically Nanostructured Electrode for Nonenzymatic Glucose Sensing

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