Thermo- and pH-sensitive dendrimer derivatives with a shell of poly(N,N-dimethylaminoethyl methacrylate) and study of their controlled drug release behavior

Smart Polymers in Drug Delivery

“…Similarly, Hiu and co-workers prepared a chlorambucil-loaded dendritic PAMAM core and poly (N, N-dimethylaminoethyl methacrylate) (PDMA) polymer system. Their study demonstrated that this combination behaved as a dual stimuli-responsive polymer by reversibly changing gelling properties exposed to a change in pH and temperature (Hu et al 2005). …”

Stimuli Responsive Carriers: Magnetically, Thermally and pH Assisted Drug Delivery

“…The release was increased up to tenfold by decreasing the pH to 2-4 [ 11 ]. Dual acting pH and thermosensitive dendrimer with a shell of poly( N , N -dimethylaminoethyl methacrylate) were also developed [ 12 ]. Similarly Yuan et al, reported pH-sensitiveness and cellular targeting dendrimer to provide the advantage of thermo regulated targeting.…”

Dendrimer-based bionanomaterials produced by surface modification, assembly and hybrid formation

“…37 Similarly, thermosensitivepoly(N,N-dimethylaminoethyl methacrylate) chains were grafted onto a PAMAM dendrimer via atom transfer radical polymerization. 38 In addition, poly(NIPAAm) with 4-nitrophenyl-carbonate-activated terminal was reacted with amine-terminated PAMAM dendrimers to obtain temperaturesensitive dendrimers. 39 These thermosensitive polymer-attached dendrimers exhibit temperature-controlled functions such as particle size, 37 catalytic activity 36 and drug-release behaviors.…”

“…39 These thermosensitive polymer-attached dendrimers exhibit temperature-controlled functions such as particle size, 37 catalytic activity 36 and drug-release behaviors. 38,39 However, dendrimers of this type are expected to exhibit a lowering of their structural uniformity. Their molecular shape might be star-like rather than spherical.…”