This article presents a novel and comprehensive approach for the thermoeconomic evaluation of subcritical and supercritical isobutane cycles for geothermal temperatures of Tgeo = 100–200 °C. The isobutane cycles are optimized with respect to the maximum net power or minimum levelized cost of electricity (LCOE). Cycle optimization is also included, using a minimum superheat temperature to avoid turbine erosion, which is usually neglected in the literature. The results show that economic optimums are found in the far superheated region, while thermal optimums are obtained with dry saturated or with slightly superheated vapor at the turbine inlet (ΔTsup < 5 °C). Supercritical cycles achieve better thermal performance than subcritical cycles for Tgeo = 179–200 °C. Internal heat recuperation improves the cycle performance: the net power output increases and the LCOE decreases, but specific installation costs (SICs) increase due to the additional heat exchanger. For geothermal temperatures of Tgeo = 120 → 150 °C, the costs are LCOE = 100 → 80 USD2022/MWh and SIC = 7000 → 5250 USD2022/kW, while for geothermal temperatures of Tgeo = 150 → 200 °C, the estimated costs are LCOE = 80 → 70 USD2022/MWh and SIC = 5250 → 4600 USD2022/kW.