Ice slurry is an advanced secondary refrigerant that has been attracting considerable attention for the past decade due to the growing concerns regarding energy shortage and environmental protection. To stimulate the potential applications of ice slurry, the corresponding pressure drop of this refrigerant must be comprehensively investigated. The flow of ice slurry is a complex phenomenon that is affected by various parameters, including flow velocity, ice particle size, and ice mass fraction. To predict the pressure drop of ice slurry flow in pipes, a mixture computational fluid dynamic model was adopted to simulate a two-phase flow without considering ice melting. The numerical calculations were performed on a wide range of six ice particle sizes (0.1, 0.3, 0.5, 0.75, 1, and 1.2 mm) and ice mass fraction ranging within 5%–20% in the laminar range of ice slurry flow. The numerical model was validated using experimental data. Results showed that the ice volumetric loading and flow velocity have a direct effect on pressure drop; it increases with the increase in volumetric concentration and flow velocity. The findings also confirmed that for constant ice mass fraction and flow velocity, the pressure drop is directly and inversely related to the particle and pipe diameters, respectively. Moreover, the rise in pressure drop is more significant for large ice particle diameter in comparison to smaller size ice particles at high values of ice concentration and flow velocity.